ArticleThe Journal of cell biology2004
T cell receptor antagonism interferes with MHC clustering and integrin patterning during immunological synapse formation.
Article in The Journal of cell biology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 42 citations in OpenAlex.
- Mapping the stochastic sequence of individual ligand-receptor binding events to cellular activation: T cells act on the rare events.Science signaling · 2019Article
- Antibodies to HLA Molecules Mimic Agonistic Stimulation to Trigger Vascular Cell Changes and Induce Allograft Injury.Current transplantation reports · 2015Article
- Leukocyte arrest: Biomechanics and molecular mechanisms of β2 integrin activation.Biorheology · 2015Review
- A peptide antagonist disrupts NK cell inhibitory synapse formation.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- How the immune system talks to itself: the varied role of synapses.Immunological reviews · 2013Review
- Self-reactive human CD4 T cell clones form unusual immunological synapses.The Journal of experimental medicine · 2012Article
- T cell recognition of weak ligands: roles of signaling, receptor number, and affinity.Immunologic research · 2011Review
- Visualization of Cell-Cell Interaction Contacts: Synapses and Kinapses.Self/nonself · 2011Article
- Shb deficient mice display an augmented TH2 response in peripheral CD4+ T cells.BMC immunology · 2011Article
- Diversity in immunological synapse structure.Immunology · 2010Review
- Antagonizing inhibition gets NK cells going.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Peptide-MHC heterodimers show that thymic positive selection requires a more restricted set of self-peptides than negative selection.The Journal of experimental medicine · 2010Article
- Modular design of immunological synapses and kinapses.Cold Spring Harbor perspectives in biology · 2009Review
- Protein kinase C theta regulates stability of the peripheral adhesion ring junction and contributes to the sensitivity of target cell lysis by CTL.Journal of immunology (Baltimore, Md. : 1950) · 2008Article
- Surface-anchored monomeric agonist pMHCs alone trigger TCR with high sensitivity.PLoS biology · 2008Article
- LFA-1-mediated T cell costimulation through increased localization of TCR/class II complexes to the central supramolecular activation cluster and exclusion of CD45 from the immunological synapse.Journal of immunology (Baltimore, Md. : 1950) · 2007Article
- The stimulatory potency of T cell antigens is influenced by the formation of the immunological synapse.Immunity · 2007Article
- Antagonism of HIV-specific CD4+ T cells by C-terminal truncation of a minimum epitope.Molecular immunology · 2006Article
- Axotrophin and leukaemia inhibitory factor (LIF) in transplantation tolerance.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2005Review
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
T cell activation by nonself peptide-major histocompatibility complex (MHC) antigenic complexes can be blocked by particular sequence variants in a process termed T cell receptor antagonism. The inhibition mechanism is not understood, although such variants are encountered in viral infections and may aid immune evasion. Here, we study the effect of antagonist peptides on immunological synapse formation by T cells. This cellular communication process features early integrin engagement and T cell motility arrest, referred to as the "stop signal." We find that synapses formed on membranes presenting antagonist-agonist complexes display reduced MHC density, which leads to reduced T cell proliferation that is not overcome by the costimulatory ligands CD48 and B7-1. Most T cells fail to arrest and crawl slowly with a dense ICAM-1 crescent at the leading edge. Similar aberrant patterns of LFA-1/ICAM-1 engagement in live T-B couples correlate with reduced calcium flux and IL-2 secretion. Hence, antagonist peptides selectively disable MHC clustering and the stop signal, whereas LFA-1 valency up-regulation occurs normally.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.