ArticleThe Journal of cell biology2004
Dynamic targeting of the replication machinery to sites of DNA damage.
Article in The Journal of cell biology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
34 citing papers in PubMed.
- PCNA encircling primer/template junctions is eliminated by exchange of RPA for Rad51: implications for the interplay between human DNA damage tolerance pathways.Nucleic acids research · 2026Article
- Article
- A requirement for STAG2 in replication fork progression creates a targetable synthetic lethality in cohesin-mutant cancers.Nature communications · 2019Article
- PCNA is recruited to irradiated chromatin in late S-phase and is most pronounced in G2 phase of the cell cycle.Protoplasma · 2017Article
- Protein dynamics of human RPA and RAD51 on ssDNA during assembly and disassembly of the RAD51 filament.Nucleic acids research · 2017Article
- Balancing self-renewal against genome preservation in stem cells: How do they manage to have the cake and eat it too?Cellular and molecular life sciences : CMLS · 2016Review
- Discrimination of Kinetic Models by a Combination of Microirradiation and Fluorescence Photobleaching.Biophysical journal · 2015Article
- Real-time imaging of DNA damage in yeast cells using ultra-short near-infrared pulsed laser irradiation.PloS one · 2014Article
- Concentration-dependent exchange of replication protein A on single-stranded DNA revealed by single-molecule imaging.PloS one · 2014Article
- Targeting telomere-containing chromosome ends with a near-infrared femtosecond laser to study the activation of the DNA damage response and DNA damage repair pathways.Journal of biomedical optics · 2013Article
- microRNA-7 suppresses the invasive potential of breast cancer cells and sensitizes cells to DNA damages by targeting histone methyltransferase SET8.The Journal of biological chemistry · 2013Article
- The nucleosome binding protein HMGN1 interacts with PCNA and facilitates its binding to chromatin.Molecular and cellular biology · 2012Article
- DNA damage in the presence of chemical genotoxic agents induce acetylation of H3K56 and H4K16 but not H3K9 in mammalian cells.Molecular biology reports · 2012Article
- BUHO: a MATLAB script for the study of stress granules and processing bodies by high-throughput image analysis.PloS one · 2012Article
- DNA-PK-dependent RPA2 hyperphosphorylation facilitates DNA repair and suppresses sister chromatid exchange.PloS one · 2011Article
- Dynamic as well as stable protein interactions contribute to genome function and maintenance.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2011Article
- Regulation of the histone H4 monomethylase PR-Set7 by CRL4(Cdt2)-mediated PCNA-dependent degradation during DNA damage.Molecular cell · 2010Article
- Coordinating DNA polymerase traffic during high and low fidelity synthesis.Biochimica et biophysica acta · 2010Review
- Analysis of replication factories in human cells by super-resolution light microscopy.BMC cell biology · 2009Article
- Protein phosphatase 2A-dependent dephosphorylation of replication protein A is required for the repair of DNA breaks induced by replication stress.Molecular and cellular biology · 2009Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Components of the DNA replication machinery localize into discrete subnuclear foci after DNA damage, where they play requisite functions in repair processes. Here, we find that the replication factors proliferating cell nuclear antigen (PCNA) and RPAp34 dynamically exchange at these repair foci with discrete kinetics, and this behavior is distinct from kinetics during DNA replication. Posttranslational modification is hypothesized to target specific proteins for repair, and we find that accumulation and stability of PCNA at sites of damage requires monoubiquitination. Contrary to the popular notion that phosphorylation on the NH2 terminus of RPAp34 directs the protein for repair, we demonstrate that phosphorylation by DNA-dependent protein kinase enhances RPAp34 turnover at repair foci. Together, these findings support a dynamic exchange model in which multiple repair factors regulated by specific modifications have access to and rapidly turn over at sites of DNA damage.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.