ArticleThe Journal of clinical investigation1992
Fibronectin expression in the normal and hypertrophic rat heart.
Article in The Journal of clinical investigation, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 68 citations in OpenAlex.
- Targeting mitochondrial shape: at the heart of cardioprotection.Basic research in cardiology · 2023Article
- Blockage of Fibronectin 1 Ameliorates Myocardial Ischemia/Reperfusion Injury in Association with Activation of AMP-LKB1-AMPK Signaling Pathway.Oxidative medicine and cellular longevity · 2022Article
- The Non-Fibrillar Side of Fibrosis: Contribution of the Basement Membrane, Proteoglycans, and Glycoproteins to Myocardial Fibrosis.Journal of cardiovascular development and disease · 2019Review
- Inspiration from heart development: Biomimetic development of functional human cardiac organoids.Biomaterials · 2017Article
- Fibronectin increases the force production of mouse papillary muscles via α5β1 integrin.Journal of molecular and cellular cardiology · 2011Article
- Morphological identification of right ventricular failure in cases of fatal pulmonary thromboembolism.International journal of legal medicine · 2011Article
- Cardiomyocyte contractile status is associated with differences in fibronectin and integrin interactions.American journal of physiology. Heart and circulatory physiology · 2010Article
- Increased fibronectin deposition in embryonic hearts of retinol-binding protein-null mice.Circulation research · 2003Article
- Alpha 4 integrins and vascular cell adhesion molecule-1 play a role in sympathetic innervation of the heart.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
- The extracellular matrix and the cytoskeleton in heart hypertrophy and failure.Heart failure reviews · 2000Review
- Expression of fibronectin splicing variants in organ transplantation: a differential pattern between rat cardiac allografts and isografts.The American journal of pathology · 1997Article
- Osteopontin is produced by rat cardiac fibroblasts and mediates A(II)-induced DNA synthesis and collagen gel contraction.The Journal of clinical investigation · 1996Article
- Expression of fibronectin ED-A+ and ED-B+ isoforms by human and experimental colorectal cancer. Contribution of cancer cells and tumor-associated myofibroblasts.The American journal of pathology · 1996Article
- Angiotensin II-induced cardiac fibrosis in the rat is increased by chronic inhibition of nitric oxide synthase.The Journal of clinical investigation · 1995Article
- Regulation of fibronectin expression in rat regenerating liver.Nucleic acids research · 1995Article
- Angiotensin II signalling pathways in cardiac fibroblasts: conventional versus novel mechanisms in mediating cardiac growth and function.Molecular and cellular biochemistryReview
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
We examined changes in the expression of fibronectin during the induction of cardiac hypertrophy by L-triiodothyronine administration and by mineralocorticoid- and salt-induced experimental hypertension. By use of Northern and Western blotting procedures, fibronectin was localized mainly in the atria of normal rat hearts. Atria contained 10- and 5-fold higher relative concentrations of fibronectin mRNA and protein, respectively, compared with ventricles. During the progression of cardiac hypertrophy induced by L-triiodothyronine over a 10-d period, there was a progressive increase in fibronectin mRNA for the first 6 d followed by a return to control levels. The major change could be accounted for by changes in ventricular mRNA, which increased about four- to sixfold. In contrast, protein levels in ventricles increased progressively over the 10-d treatment period. Ribonuclease protection analysis indicated that the relative amounts of fibronectin isoforms containing exons designated EIIIA and EIIIB increased during the progression of hypertrophy. When cardiac hypertrophy was induced by mineralocorticoid and salt treatment, increases in ventricular fibronectin mRNA and protein and the induction of alternatively spliced forms of fibronectin were also observed. However, the extent and temporal pattern of fibronectin expression differed between the two experimental models.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.