ArticleCurrent controlled trials in cardiovascular medicine2004
Equivalence and noninferiority trials - are they viable alternatives for registration of new drugs? (III).
Article in Current controlled trials in cardiovascular medicine, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed.
- Efficacy of percutaneous versus intradermal BCG in the prevention of tuberculosis in South African infants: randomised trial.BMJ (Clinical research ed.) · 2008Trial
- Comparison of In-Vitro and In-Vivo Drug Release of Dexamethasone/PLGA Intravitreal Implants Using Two In-Vitro Release Methods and a Rabbit Model.Molecular pharmaceutics · 2025Article
- A Preclinical Study Comparing the Activity and Potency of OnabotulinumtoxinA and PrabotulinumtoxinA.Clinical, cosmetic and investigational dermatology · 2023Article
- Medicines withdrawn in other countries due to safety concerns: should they continue to be available in the Argentine pharmaceutical market?Revista de la Facultad de Ciencias Medicas (Cordoba, Argentina) · 2022Article
- Performance comparison of single-view digital breast tomosynthesis plus single-view digital mammography with two-view digital mammography.European radiology · 2013Article
- Modelling of the outcome of non-inferiority trials by integration of historical data.Journal of pharmacokinetics and pharmacodynamics · 2011Article
- Non-inferiority clinical trials: Practical issues and current regulatory perspective.Indian journal of pharmacology · 2011Article
- Swimming upstream: comparative effectiveness research in the US.PharmacoEconomics · 2009Article
- Methodological considerations in the design of trials for safety assessment of new drugs and chemical entities.Current controlled trials in cardiovascular medicine · 2005Article
- Equivalence trials.Perspectives in clinical researchArticle
- Understanding Superiority, Noninferiority, and Equivalence for Clinical Trials.Indian dermatology online journalReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The scientific community's reliance on active-controlled trials is steadily increasing, as widespread agreement emerges concerning the role of these trials as viable alternatives to placebo trials. These trials present substantial challenges with regard to design and interpretation as their complexity increases, and the potential need for larger sample sizes impacts the cost and time variables of the drug development process. The potential efficacy and safety benefits derived from these trials may never be demonstrated by other methods. Active-controlled trials can develop valuable data to inform both prescribers and patients about the dose- and time-dependent actions of any new drug and can contribute to the management and communication of risks associated with the relevant therapeutic products.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.