ArticleCritical care (London, England)2004
Influence of insulin on glucose metabolism and energy expenditure in septic patients.
Article in Critical care (London, England), 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01347801 (Mechanisms of Insulin Resistance in Critical Illness), which is not on this map. Cited by 6 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Mechanisms of Insulin Resistance in Critical Illness: Role of Systemic Inflammation and GLP-1
Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- Methodological Aspects of Indirect Calorimetry in Patients with Sepsis-Possibilities and Limitations.Nutrients · 2022Pooled it
- Low Insulin Is an Independent Predictor of All-Cause and Cardiovascular Death in Acute Decompensated Heart Failure Patients Without Diabetes Mellitus.Journal of the American Heart Association · 2020Article
- Glucose variability and mortality in patients with sepsis.Critical care medicine · 2008Article
- Caecal ligation and puncture in the rat mimics the pathophysiological changes in human sepsis and causes multi-organ dysfunction.Metabolic brain disease · 2007Article
- Year in review in Critical Care, 2004: sepsis and multi-organ failure.Critical care (London, England) · 2005Review
- Insulin and metabolic substrates during human sepsis.Critical care (London, England) · 2004Article
Corrections and comments
- Commented on by
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionIt is recognized that administration of insulin with glucose decreases catabolic response in sepsis. The aim of the present study was to compare the effects of two levels of insulinaemia on glucose metabolism and energy expenditure in septic patients and volunteers.
methodsGlucose uptake, oxidation and storage, and energy expenditure were measured, using indirect calorimetry, in 20 stable septic patients and 10 volunteers in a two-step hyperinsulinaemic (serum insulin levels 250 and 1250 mIU/l), euglycaemic (blood glucose concentration 5 mmol/l) clamp. Differences between steps of the clamp (from serum insulin 1250 to 250 mIU/l) for all parameters were calculated for each individual, and compared between septic patients and volunteers using the Wilcoxon nonpaired test.
resultsDifferences in glucose uptake and storage were significantly less in septic patients. The differences in glucose oxidation between the groups were not statistically significant. Baseline energy expenditure was significantly higher in septic patients, and there was no significant increase in either step of the clamp in this group; when comparing the two groups, the differences between steps were significantly greater in volunteers.
conclusionA hyperdynamic state of sepsis leads to a decrease in glucose uptake and storage in comparison with healthy volunteers. An increase in insulinaemia leads to an increase in all parameters of glucose metabolism, but the increases in glucose uptake and storage are significantly lower in septic patients. A high level of insulinaemia in sepsis increases glucose uptake and oxidation significantly, but not energy expenditure, in comparison with volunteers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.