ArticleThe Journal of cell biology1992
Microinjected U snRNAs are imported to oocyte nuclei via the nuclear pore complex by three distinguishable targeting pathways.
Article in The Journal of cell biology, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed, 93 citations in OpenAlex.
- Nuclear export factor 3 regulates localization of small nucleolar RNAs.The Journal of biological chemistry · 2017Article
- An in vitro assay for entry into cilia reveals unique properties of the soluble diffusion barrier.The Journal of cell biology · 2013Article
- Involvement of nuclear import and export factors in U8 box C/D snoRNP biogenesis.Molecular and cellular biology · 2007Article
- Uncapped mRNA introduced into tobacco protoplasts can be imported into the nucleus and is trapped by leptomycin B.Plant cell reports · 2004Article
- Importin beta-depending nuclear import pathways: role of the adapter proteins in the docking and releasing steps.Molecular biology of the cell · 2003Article
- The importin-beta binding domain of snurportin1 is responsible for the Ran- and energy-independent nuclear import of spliceosomal U snRNPs in vitro.The Journal of cell biology · 2002Article
- The snoRNA domain of vertebrate telomerase RNA functions to localize the RNA within the nucleus.RNA (New York, N.Y.) · 2001Article
- snoRNA nuclear import and potential for cotranscriptional function in pre-rRNA processing.RNA (New York, N.Y.) · 2001Article
- Import of Agrobacterium T-DNA into plant nuclei: two distinct functions of VirD2 and VirE2 proteins.The Plant cell · 2001Article
- Functional analysis of the simian immunodeficiency virus Vpx protein: identification of packaging determinants and a novel nuclear targeting domain.Journal of virology · 2001Article
- Functional characterization of nuclear localization signals in yeast Sm proteins.Molecular and cellular biology · 2000Article
- The spinal muscular atrophy disease gene product, SMN: A link between snRNP biogenesis and the Cajal (coiled) body.The Journal of cell biology · 1999Article
- Importin beta can mediate the nuclear import of an arginine-rich nuclear localization signal in the absence of importin alpha.Molecular and cellular biology · 1999Article
- A novel nuclear import pathway for the transcription factor TFIIS.The Journal of cell biology · 1998Article
- Modifications of U2 snRNA are required for snRNP assembly and pre-mRNA splicing.The EMBO journal · 1998Article
- Snurportin1, an m3G-cap-specific nuclear import receptor with a novel domain structure.The EMBO journal · 1998Article
- A nuclear import pathway for a protein involved in tRNA maturation.The Journal of cell biology · 1997Article
- Nuclear import of U snRNPs requires importin beta.The EMBO journal · 1997Article
- A role for the M9 transport signal of hnRNP A1 in mRNA nuclear export.The Journal of cell biology · 1997Article
- In vivo selection of RNAs that localize in the nucleus.The EMBO journal · 1997Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The inhibitory effects of wheat germ agglutinin and mAb 414 on the nuclear import of all types of U snRNAs indicate that they cross the nuclear envelope through the nuclear pore complex. However, the import of different U snRNAs occurs by kinetically distinct targeting pathways that can be distinguished from one another by the competitive effects of free trimethylguanosine cap dinucleotide (m3GpppG) and P(Lys)-BSA, an efficient synthetic karyophile based on the nuclear localization signal of SV40 large T antigen. The import of U snRNAs that contain 5' m3GpppN caps and are complexed by Sm proteins (U1, U2, U4, and U5) is competed by coinjection with free m3GpppG, indicating a shared transport factor, but not by P(Lys)-BSA. The import of U6 snRNA, which lacks a m3GpppN cap and is not complexed by the Sm proteins, is competed by P(Lys)-BSA but not by free m3GpppG. Thus, by the criterion of kinetic competition, U6 snRNA import is identical to that of the karyophilic proteins P(Lys)-BSA and nucleoplasmin. Uniquely, the import of U3 snRNA, which contains a m3GpppN cap but does not bind Sm proteins is not competed by either free m3GpppG or P(Lys)-BSA. Thus, U3 snRNA appears to be imported by a novel third kinetic pathway.
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