ReviewThe Journal of urology2004
Mechanisms in prostatitis/chronic pelvic pain syndrome.
Review in The Journal of urology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 89 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
89 citing papers in PubMed, 2 syntheses or guidelines pooled it, 354 citations in OpenAlex.
- Non-pharmacological interventions for treating chronic prostatitis/chronic pelvic pain syndrome.The Cochrane database of systematic reviews · 2018Pooled it
- Non-pharmacological interventions for treating chronic prostatitis/chronic pelvic pain syndrome.The Cochrane database of systematic reviews · 2018Pooled it
- Outcomes and clinical predictors of extracorporeal shock wave therapy in the treatment of chronic prostatitis/chronic pelvic pain syndrome: a prospective randomized double-blind placebo-controlled clinical trial.Prostate cancer and prostatic diseases · 2022Trial
- [Long-term effects of osteopathic treatment of chronic prostatitis with chronic pelvic pain syndrome: a 5-year follow-up of a randomized controlled trial and considerations on the pathophysiological context].Der Urologe. Ausg. A · 2013Trial
- [Chronic prostatitis/chronic pelvic pain syndrome. Influence of osteopathic treatment - a randomized controlled study].Der Urologe. Ausg. A · 2009Trial
- [Intraprostatic botulinum toxin A injection in chronic prostatitis and chronic pelvic pain syndrome (CP/CPPS)].Der Urologe. Ausg. A · 2007Trial
- Efficacy and safety of Shulie'an capsules in treating chronic prostatitis: A multicenter, prospective, open-label clinical trial.Journal of translational internal medicine · 2026Article
- Mechanism of Bao Jing Tablets in Chronic Prostatitis/Chronic Pelvic Pain Syndrome: Insights from Multi-Omics and Network Pharmacology.Pharmaceuticals (Basel, Switzerland) · 2026Article
- Neurobiology of Anxiety and Depression in CP/CPPS: A Narrative Review of Underlying Mechanisms.Neurology international · 2026Review
- A Chinese expert consensus on prostate-pelvic syndrome.Current urology · 2026Article
- Slow Releasing CO Donor Modulates Susceptibility to Seizures in Rats with Chronic Prostatitis/Chronic Pelvic Pain Syndrome: Behavioral and EEG Study.Medicina (Kaunas, Lithuania) · 2025Article
- Case Report: Chronic Prostatitis as an Extraintestinal Manifestation of Ulcerative Colitis.IJU case reports · 2025Article
- Transcatheter Arterial Embolization for Chronic Prostatitis/Chronic Pelvic Pain Syndrome: A Retrospective Study of 44 Patients.Cardiovascular and interventional radiology · 2024Article
- Extracellular Domain of IL-10 Receptor Chain-2 (IL-10R2) and Its Arginine-Containing Peptides Are Susceptible Substrates for Human Prostate Kallikrein-2 (KLK2).Biochemistry · 2024Article
- Research progress on the relationship between chronic prostatitis/chronic pelvic pain syndrome and the microbiota of the reproductive system.Frontiers in cellular and infection microbiology · 2024Review
- Anogenital distance in the etiology of chronic prostatitis: does it lead to novel surgical treatments?Frontiers in urology · 2024Article
- Chronic Primary Pelvic Pain Syndrome in Men.Deutsches Arzteblatt international · 2023Review
- A Bibliometric Analysis of Urologic Chronic Pelvic Pain Syndrome From 2000 to 2022.Journal of pain research · 2023Article
- Chronic Prostatitis/Chronic Pelvic Pain Syndrome Induces Depression-Like Behavior and Learning-Memory Impairment: A Possible Link with Decreased Hippocampal Neurogenesis and Astrocyte Activation.Oxidative medicine and cellular longevity · 2023Article
- Low intensity extracorporeal shockwave therapy for chronic pelvic pain syndrome: Long-term follow-up.Open medicine (Warsaw, Poland) · 2023Article
29 more citing papers are in PubMed but not listed here.
Corrections and comments
- Reprinted as
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
purposeWe reviewed the current literature on mechanisms involved in the pathogenesis of prostatitis/chronic pelvic pain syndrome (CPPS). MATERIALS AND
methodsA literature review for the years 1966 to 2003 was performed using the MEDLINE database of the United States National Library of Medicine.
resultsNational Institutes of Health categories I and II prostatitis result from identifiable prostatic infections, whereas patients with category IV are asymptomatic. The majority of symptomatic cases are category III or chronic prostatitis (CP)/CPPS. The etiology of CP/CPPS is unknown. The traditional marker of inflammation, namely white blood cells in prostatic fluids, does not correlate with the predominant symptom of pelvic pain. An imbalance toward increased proinflammatory and decreased anti-inflammatory cytokines has been implicated and a few studies have shown some correlation of this with pelvic pain. The imbalance in some men may result from polymorphisms at the cytokine loci. An autoimmune process may be involved and experimental evidence indicates that this can be under hormonal influence. Recent findings include possible defects in the androgen receptor. The prostate may not even be the source of the symptoms. Pelvic pain also correlates with the neurotrophin nerve growth factor implicated in neurogenic inflammation and central sensitization. Finally, psychological stress may produce measurable biochemical changes and influence the other processes. The role of normal prostatic bacterial flora in inciting the inflammatory response has also been reconsidered.
conclusionsThe symptoms of CP/CPPS appear to result from an interplay between psychological factors and dysfunction in the immune, neurological and endocrine systems.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.