ArticleWorld journal of gastroenterology2004
Clinical significance of serum IGF-I, IGF-II and IGFBP-3 in liver cirrhosis.
Article in World journal of gastroenterology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 63 citations in OpenAlex.
- Knockout of IGFBP3 improves alcohol-induced liver injury via Akt/GSK3β and TMEM219/caspase 8 pathways.Frontiers in physiology · 2026Article
- Exposure to PFAS chemicals induces sex-dependent alterations in key rate-limiting steps of lipid metabolism in liver steatosis.Frontiers in toxicology · 2024Article
- IGF2-NR4A2 Signaling Regulates Macrophage Subtypes to Attenuate Liver Cirrhosis.Journal of clinical and translational hepatology · 2023Article
- Insulin-like growth factor 1 predicts decompensation and long-term prognosis in patients with compensated cirrhosis.Frontiers in medicine · 2023Article
- Article
- Association between immunologic markers and cirrhosis in individuals with chronic hepatitis B.Scientific reports · 2021Article
- Observational
- Insulin-Like Growth Factor (IGF) System in Liver Diseases.International journal of molecular sciences · 2018Review
- Insulin-like growth factor type 1 concentrations in hyperthyroid cats before and after treatment with thiamazole.Journal of feline medicine and surgery · 2018Article
- Article
- Predictive factors of short term outcome after liver transplantation: A review.World journal of gastroenterology · 2016Review
- Circulating insulin-like growth factor-binding protein 3 as prognostic biomarker in liver cirrhosis.World journal of hepatology · 2016Article
- Type I insulin-like growth factor as a liver reserve assessment tool in hepatocellular carcinoma.Journal of hepatocellular carcinoma · 2015Review
- Postoperative Insulin-Like Growth Factor 1 Levels Reflect the Graft's Function and Predict Survival after Liver Transplantation.PloS one · 2015Article
- Development and validation of insulin-like growth factor-1 score to assess hepatic reserve in hepatocellular carcinoma.Journal of the National Cancer Institute · 2014Article
- A survey of correlation between insulin-like growth factor-I (igf-I) levels and severity of liver cirrhosis.Hepatitis monthly · 2013Article
- Serum IGFBP-3 is a more effective predictor than IGF-1 and IGF-2 for the development of hepatocellular carcinoma in patients with chronic HCV infection.Oncology letters · 2012Article
- Alterations of insulin-like growth factor I (IGF-I) and estradiol serum levels in chronic hepatitis C.Contemporary oncology (Poznan, Poland) · 2012Article
- Serum prolidase and IGF-1 as non-invasive markers of hepatic fibrosis during four different periods after bile-duct ligation in rats.Digestive diseases and sciences · 2008Article
- Rapid identification of promoter hypermethylation in hepatocellular carcinoma by pyrosequencing of etiologically homogeneous sample pools.The Journal of molecular diagnostics : JMD · 2007Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo investigate the relationship between insulin-like growth factor-I, -II (IGF-I and IGF-II), IGF-binding protein 3 (IGFBP-3) and Child-Pugh score in patients with liver cirrhosis, and to search for potential clinical markers of liver function.
methodsForty-four patients with advanced liver cirrhosis of viral origin were divided into 3 groups according to severity of cirrhosis (Child-Pugh score) and 38 healthy subjects served as controls. Serum levels of IGF-I, IGF-II and IGFBP-3 were measured by immunoradiometric assay.
resultsSerum IGF-I, IGF-II and IGFBP-3 levels were significantly lower in patients with cirrhosis than in controls, and serum concentrations of IGF-I, IGF-II and IGFBP-3 were associated with the severity of liver dysfunction, and dropped sharply during the progression of liver failure. Among these 3 parameters, serum IGF-II was the most sensitive and effective indicator for liver dysfunction. Concentrations of IGF-I <30 ng/mL, IGF-II <200 ng/mL and IGFBP-3 <6 ng/mL implied a negative prognosis for patients with liver cirrhosis.
conclusionSerum IGF-I, IGF-II and IGFBP-3 may provide a new dimension in the assessment of liver dysfunction. Combined detection of serum IGF-I, IGF-II and IGFBP-3 with Child-Pugh score is more effective in predicting prognosis than Child-Pugh score alone.
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Registered trials
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