ArticleAmerican journal of human genetics2004
The interleukin 1 gene cluster contains a major susceptibility locus for ankylosing spondylitis.
Article in American journal of human genetics, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
38 citing papers in PubMed, 3 syntheses or guidelines pooled it, 128 citations in OpenAlex.
- Pooled it
- Comprehensive association study of genetic variants in the IL-1 gene family in systemic juvenile idiopathic arthritis.Genes and immunity · 2008Pooled it
- Novel non-HLA-susceptible regions determined by meta-analysis of four genomewide scans for ankylosing spondylitis.Journal of genetics · 2008Pooled it
- The gut-bone axis in ankylosing spondylitis: mechanistic insights and the translational gap.Clinical and experimental medicine · 2025Review
- Using genetic association data to guide drug discovery and development: Review of methods and applications.American journal of human genetics · 2023Review
- Disentangling the effects of traits with shared clustered genetic predictors using multivariable Mendelian randomization.Genetic epidemiology · 2022Article
- Cytokine "fine tuning" of enthesis tissue homeostasis as a pointer to spondyloarthritis pathogenesis with a focus on relevant TNF and IL-17 targeted therapies.Seminars in immunopathology · 2021Review
- Identification of RELN variant p.(Ser2486Gly) in an Iranian family with ankylosing spondylitis; the first association of RELN and AS.European journal of human genetics : EJHG · 2020Article
- Genetic polymorphisms in IL1B predict susceptibility to steroid-induced osteonecrosis of the femoral head in Chinese Han population.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2019Article
- IL-1A gene variation in relation to cytokine levels and clinical characteristics in ankylosing spondylitis.European journal of rheumatology · 2019Article
- Association of IL-1A and IL-1B polymorphisms with ankylosing spondylitis among the Chinese Han population: a case-control study.Oncotarget · 2017Article
- Association of rs11209032 and rs1004819 Polymorphisms in Interleukin-23 Receptor Gene With Ankylosing Spondylitis.Archives of rheumatology · 2016Article
- Ankylosing spondylitis: A state of the art factual backbone.World journal of radiology · 2015Review
- The effect of IL-4 and MTHFR gene variants in ankylosing spondylitis.Zeitschrift fur Rheumatologie · 2015Article
- Cytokine production associated with smallpox vaccine responses.Immunotherapy · 2014Review
- The genetic basis of ankylosing spondylitis: new insights into disease pathogenesis.The application of clinical genetics · 2014Review
- Distribution of the IL-1RN, IL-6, IL-10, INF-γ, and TNF-α Gene Polymorphisms in the Mexican Population.Genetic testing and molecular biomarkers · 2012Article
- Genetics of spondyloarthritis--beyond the MHC.Nature reviews. Rheumatology · 2012Review
- IL1 gene polymorphisms in enthesitis related arthritis category of juvenile idiopathic arthritis (ERA-JIA).Clinical rheumatology · 2012Article
- Single-nucleotide polymorphisms and expression of IL23R in Chinese ankylosing spondylitis patients.Rheumatology international · 2010Article
Corrections and comments
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Authors and funding
14 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ankylosing spondylitis (AS) is a common and highly heritable inflammatory arthropathy. Although the gene HLA-B27 is almost essential for the inheritance of the condition, it alone is not sufficient to explain the pattern of familial recurrence of the disease. We have previously demonstrated suggestive linkage of AS to chromosome 2q13, a region containing the interleukin 1 (IL-1) family gene cluster, which includes several strong candidates for involvement in the disease. In the current study, we describe strong association and transmission of IL-1 family gene cluster single-nucleotide polymorphisms and haplotypes with AS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.