ArticleDevelopment genes and evolution2004
her11 is involved in the somitogenesis clock in zebrafish.
Article in Development genes and evolution, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 45 citations in OpenAlex.
- Temporal and Spatial Variations in ZebrafishInternational journal of molecular sciences · 2024Article
- A network of Notch-dependent and -independent her genes controls neural stem and progenitor cells in the zebrafish thalamic proliferation zone.Development (Cambridge, England) · 2023Article
- Zebrafish her3 knockout impacts developmental and cancer-related gene signatures.Developmental biology · 2023Article
- Species-specific roles of the Notch ligands, receptors, and targets orchestrating the signaling landscape of the segmentation clock.Frontiers in cell and developmental biology · 2023Review
- An Update on the Molecular Mechanism of the Vertebrate Isthmic Organizer Development in the Context of the Neuromeric Model.Frontiers in neuroanatomy · 2022Review
- The vertebrate Embryo Clock: Common players dancing to a different beat.Frontiers in cell and developmental biology · 2022Review
- Article
- The Her7 node modulates the network topology of the zebrafish segmentation clock via sequestration of the Hes6 hub.Development (Cambridge, England) · 2012Article
- Topology and dynamics of the zebrafish segmentation clock core circuit.PLoS biology · 2012Article
- Evolutionary plasticity of segmentation clock networks.Development (Cambridge, England) · 2011Article
- Zebrafish Her8a is activated by Su(H)-dependent Notch signaling and is essential for the inhibition of neurogenesis.PloS one · 2011Article
- Expression of myriapod pair rule gene orthologs.EvoDevo · 2011Article
- Cyclic Nrarp mRNA expression is regulated by the somitic oscillator but Nrarp protein levels do not oscillate.Developmental dynamics : an official publication of the American Association of Anatomists · 2009Article
- Expression of the oscillating gene her1 is directly regulated by Hairy/Enhancer of Split, T-box, and Suppressor of Hairless proteins in the zebrafish segmentation clock.Developmental dynamics : an official publication of the American Association of Anatomists · 2009Article
- Lunatic fringe promotes the lateral inhibition of neurogenesis.Development (Cambridge, England) · 2009Article
- Notch signalling synchronizes the zebrafish segmentation clock but is not needed to create somite boundaries.PLoS genetics · 2008Article
- Zebrafish hairy/enhancer of split protein links FGF signaling to cyclic gene expression in the periodic segmentation of somites.Genes & development · 2005Article
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3 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Somitogenesis requires an intricate process of pre-patterning, which is driven by an oscillator mechanism consisting of the Delta-Notch pathway and hairy- (h) and Enhancer of split- [E(spl)] related genes. With the aim of unravelling the complex mechanism of somite pre-patterning, we have conducted an extensive search for h/E(spl)-related genes in the third release of the Danio rerio genomic sequence. We identified 14 new h/E(spl) genes and analysed them by in situ hybridisation for their potential role in the somitogenesis process. We describe here the functional analysis of one of these genes, which we have named her11. her11 is a paralogue of her1 and, similar to her1, is arranged in a head to head fashion with another her gene, namely the previously described her5. It shares an expression in the midbrain-hindbrain boundary with her5, but is in addition cyclically expressed in patterns overlapping those of her1 and her7 and complementary to those of hey1. Furthermore it is expressed in the anterior half of the most caudally formed somites. We show that Delta-Notch pathway genes and fused somites ( fss) are necessary for the control of her11 expression. However, some aspects of the her11 regulation suggest that at least one additional as yet unknown gene of the Delta-Notch cascade is required to explain its expression. Morpholino-oligonucleotide-mediated knockdown of her11 shows that it is involved in the zebrafish somitogenesis clock via an interaction with her1 and her7. We have also studied the role of hey1 by morpholino injection, but could not find a direct function for this gene, suggesting that it reflects the output of the clock rather than being a core component of the mechanism.
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