ArticlePediatric nephrology (Berlin, Germany)2004
Up-regulation of interleukin-2 mRNA in children with idiopathic nephrotic syndrome.
Article in Pediatric nephrology (Berlin, Germany), 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 42 citations in OpenAlex.
- Article
- Swollen Feet: Considering the Paradoxical Roles of Interleukins in Nephrotic Syndrome.Biomedicines · 2024Review
- The immunopathogenesis of idiopathic nephrotic syndrome: a narrative review of the literature.European journal of pediatrics · 2022Review
- A Case of Minimal Change Disease after SARS-CoV-2 Vaccination under the Age of 18.Avicenna journal of medicine · 2022Article
- Multidimensional inflammatory and immunological endotypes of idiopathic focal segmental glomerulosclerosis and their association with treatment outcomes.Clinical kidney journal · 2021Article
- Activation of the acute inflammatory phase response in idiopathic nephrotic syndrome: association with clinicopathological phenotypes and with response to corticosteroids.Clinical kidney journal · 2021Article
- Pathogenesis and Management of Acute Kidney Injury in Patients with Nephrotic Syndrome Due to Primary Glomerulopathies.Medicina (Kaunas, Lithuania) · 2019Review
- Rituximab Use in the Management of Childhood Nephrotic Syndrome.Frontiers in pediatrics · 2019Review
- Rituximab in Minimal Change Disease: Mechanisms of Action and Hypotheses for Future Studies.Canadian journal of kidney health and disease · 2017Review
- Pathogenesis of minimal change nephrotic syndrome: an immunological concept.Korean journal of pediatrics · 2016Review
- Activation of the IL-2 Receptor in Podocytes: A Potential Mechanism for Podocyte Injury in Idiopathic Nephrotic Syndrome?PloS one · 2016Article
- Role of basophils in the pathogenesis of minimal change nephrotic syndrome: A literature review.Experimental and therapeutic medicine · 2014Article
- Immune and inflammatory role in renal disease.Comprehensive Physiology · 2013Review
- Idiopathic nephrotic syndrome and atopy: is there a common link?American journal of kidney diseases : the official journal of the National Kidney Foundation · 2009Review
- Remission of refractory minimal change nephrotic syndrome after basiliximab therapy.Pediatric nephrology (Berlin, Germany) · 2009Article
- Nephrotic syndrome preceding psoriasis in children.Pediatric nephrology (Berlin, Germany) · 2007Article
- Expression of multidrug resistance P-glycoprotein on lymphocytes from nephrotic children treated with cyclosporine A and ACE-inhibitor.European journal of pediatrics · 2007Article
- A case of unfulfilled expectations. Cytokines in idiopathic minimal lesion nephrotic syndrome.Pediatric nephrology (Berlin, Germany) · 2006Review
- Effect of tumor necrosis factor alpha and vascular permeability growth factor on albuminuria in rats.Pediatric nephrology (Berlin, Germany) · 2006Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The current hypothesis for the pathogenesis of childhood idiopathic nephrotic syndrome (INS) favors the involvement of a T cell-mediated immune response. Various cytokines derived from T cells may play a critical role in INS. Previous studies have measured serum or urine cytokine levels and suggest an imbalance of the T cell-mediated immune response. To elucidate the true profile of T cell-derived cytokines, we determined interleukin (IL)-2, interferon (IFN)-gamma, IL-4, IL-10, and tumor necrosis factor (TNF)-alpha mRNA expression in children with INS. We collected mRNA from peripheral blood mononuclear cells together with plasma and urine from nine children in the acute and remission phases of INS. Expression of IL-2, IFN-gamma, IL-4, IL-10, and TNF-alpha mRNA was determined by a quantitative real-time PCR assay. Plasma and urine cytokine concentrations were measured using a specific enzyme-linked immunosorbent assay. These data were compared between the acute and remission phase in the same patients. The IL-2 mRNA levels were significantly higher in the acute phase than in the remission phase, whilst no significant difference was found in the other cytokines investigated. There was no significant difference in the plasma and urine cytokine concentrations between the acute and remission phase. Our results indicate increased expression of IL-2 mRNA in the acute phase of INS, suggesting that IL-2, at least in part, might be involved in the pathophysiology of childhood INS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.