Evidence map›Paper›PMID 15309547›Full record

Trial reportEuropean journal of applied physiology2004

Effects of dietary supplementation with vitamins C and E on muscle function during and after eccentric contractions in humans.

A Shafat, P Butler, R L Jensen, A E Donnelly

Abstract readClinical TrialRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in European journal of applied physiology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Antioxidants for preventing and reducing muscle soreness after exercise.The Cochrane database of systematic reviews · 2017
    Pooled it
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  17. Antioxidants and Exercise Performance: With a Focus on Vitamin E and C Supplementation.International journal of environmental research and public health · 2020
    Review
  18. Nutrition and microRNAs: Novel Insights to Fight Sarcopenia.Antioxidants (Basel, Switzerland) · 2020
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

A ShafatDepartment of Physical Education and Sport Sciences, University of Limerick, Limerick, Ireland. amir.shafat@ul.ie
P Butler
R L Jensen
A E Donnelly

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Reactive oxygen species may contribute to exercise-induced skeletal muscle damage, and antioxidants may protect against such damage. This study examined the effectiveness of prophylactic supplementation with vitamins C and E on symptoms of muscle damage in a single blind, two-group study design. Twelve male volunteers were randomly assigned to either treatment or control groups. The treatment group received 500 mg of vitamin C and 1,200 IU of alpha-tocopherol daily and the control group received glucose placebo for 37 days. After 30 days of treatment, volunteers performed 300 maximal eccentric contractions of the knee extensor muscles of one leg. Maximal voluntary isometric contraction force and electrically evoked force at a frequency of 20 Hz and 50 Hz were recorded before and after exercise, and on days 1, 2 and 7 after exercise. Muscle soreness questionnaires were completed and muscle girth recorded at the same time points. Eccentric contractile torque and work during the bout declined significantly in both groups ( P<0.001), but this decline was smaller in the vitamin-supplemented group ( P<0.05). Maximal voluntary isometric contraction force and 20:50 Hz force ratio declined significantly after exercise in both groups ( P<0.01), but the decline was smaller in the treatment group on days 1 and 2 post-exercise ( P<0.05). Both groups experienced similar significant muscle soreness and swelling after exercise. These data suggest that prior supplementation with dietary antioxidants ameliorates muscle functional decrements subsequent to eccentric muscle contraction.

Indexed as

Dietary SupplementsAdministration, OralAdultAntioxidantsAscorbic AcidDrug CombinationsHumansMaleMuscle ContractionMuscle FatigueMuscle, SkeletalPlacebo EffectSingle-Blind MethodVitamin EAntioxidantsAscorbic AcidDrug CombinationsVitamin E

Identifiers

PMID15309547

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.