ArticleCurrent genetics2004
Cryptococcus neoformans mitochondrial genomes from serotype A and D strains do not influence virulence.
Article in Current genetics, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
32 citing papers in PubMed.
- Article
- Essential genes encoded by the mating-type locus of the human fungal pathogenbioRxiv : the preprint server for biology · 2024Article
- The Rabbit Model of Cryptococcal Meningitis.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Overexpression of the White Opaque Switching Master Regulator Wor1 Alters Lipid Metabolism and Mitochondrial Function inJournal of fungi (Basel, Switzerland) · 2022Article
- Methods for ManipulatingJournal of fungi (Basel, Switzerland) · 2021Review
- Article
- An intergenic "safe haven" region in Cryptococcus neoformans serotype D genomes.Fungal genetics and biology : FG & B · 2020Article
- The Pheromone and Pheromone Receptor Mating-Type Locus Is Involved in Controlling Uniparental Mitochondrial Inheritance inGenetics · 2020Article
- Review
- Life Cycle ofAnnual review of microbiology · 2019Review
- Deletion of the sex-determining geneMobile DNA · 2018Article
- Cryptococcus gattii VGIII isolates causing infections in HIV/AIDS patients in Southern California: identification of the local environmental source as arboreal.PLoS pathogens · 2014Article
- Rapid mechanisms for generating genome diversity: whole ploidy shifts, aneuploidy, and loss of heterozygosity.Cold Spring Harbor perspectives in medicine · 2014Review
- Origins of eukaryotic sexual reproduction.Cold Spring Harbor perspectives in biology · 2014Review
- Sex determination directs uniparental mitochondrial inheritance in Phycomyces.Eukaryotic cell · 2014Article
- Mitochondria influence CDR1 efflux pump activity, Hog1-mediated oxidative stress pathway, iron homeostasis, and ergosterol levels in Candida albicans.Antimicrobial agents and chemotherapy · 2013Article
- Congenic strains for genetic analysis of virulence traits in Cryptococcus gattii.Infection and immunity · 2013Article
- Article
- Global transcriptome profile of Cryptococcus neoformans during exposure to hydrogen peroxide induced oxidative stress.PloS one · 2013Article
- Transmission of Hypervirulence traits via sexual reproduction within and between lineages of the human fungal pathogen cryptococcus gattii.PLoS genetics · 2013Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Cryptococcus neoformans is an encapsulated pathogenic yeast producing meningoencephalitis. Two primary strains in genetic studies, serotype A H99 and serotype D JEC21, possess dramatic differences in virulence. Since it has been shown that mitochondrial gene expression is prominent at the site of the infection and there are significant differences between mitochondrial gene structure and regulation between the serotype A and D strains, this study used AD hybrids to move serotype A and D mitochondria under different genomic influences. When the serotype D MATa strain is involved in the mating crosses, there is uniparental transmission of mitochondrial DNA, but with the serotype A MATa strain, mitochondrial DNA can be inherited from either parent and recombination in the mitochondrial genome may also occur. In virulence studies between serotype A and D strains, it was found that the primary genetic control of the virulence composite for growth in the central nervous system is encoded in the nuclear DNA and not through mitochondrial DNA.
Indexed as
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Registered trials
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