Evidence map›Paper›PMID 15309418›Full record

Trial reportEuropean journal of nutrition2004

The effect of milk fermented by yogurt cultures plus Lactobacillus casei DN-114001 on the immune response of subjects under academic examination stress.

Ascensión Marcos, Julia Wärnberg, Esther Nova, Sonia Gómez, Alberto Alvarez, Rocío Alvarez, José A Mateos, José M Cobo

Registry-linked trialAbstract readClinical TrialRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in European journal of nutrition, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03494725 (Proof-of-Concept "Stress & Anxiety Dampening Effects of Lpc-37"), which is not on this map. Cited by 39 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 11 pooled it
9.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03494725 nacompletednot on this mapstarted 2018, after this paper: background citation

Proof-of-Concept "Stress & Anxiety Dampening Effects of Lpc-37"

TypeinterventionalSponsorDaacroRan2018 to 2018Enrolled120ConditionsHealthy, Stress, PsychologicalArmsLpc-37, Placebo
3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 11 syntheses or guidelines pooled it, 115 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Ascensión MarcosGrupo Inmunonutrición, Depo. de Metabolismo y Nutrición, Instituto del Frío, CSIC, C/Jose Antonio Novais 10, 28040 Madrid, Spain. amarcos@if.csic.es
Julia Wärnberg
Esther Nova
Sonia Gómez
Alberto Alvarez
Rocío Alvarez
José A Mateos
José M Cobo
Instituto de Ciencia y Tecnología de Alimentos y Nutrición · ESInstituto de Salud Carlos III · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundA suppressed immune response has been documented in students under examination stress.

aimsThe current study aimed to evaluate the effect of milk fermented with yogurt cultures plus Lactobacillus casei DN-114001 (Actimel) on the immune system of subjects under academic examination stress.

methodsUniversity students were allocated to one of two groups, receiving during 6 weeks (3 weeks prior to, as well as the 3-week duration of the examination period) either: a) a glass of semi-skimmed milk each day (control group, n=63) or b) two 100mL portions per day of fermented milk (treatment group, n=73). Anxiety and immunological measurements were monitored at baseline (Phase 0) and study end (Phase 1).

resultsThe results were expressed as the differences between the data obtained from Phase 0 and Phase 1. This was calculated by subtracting Phase 1 results from the Phase 0 and it is denominated "Treatment effect". Mean (+/- SE) anxiety increased significantly (P<0.05) over the 6-week study in all students, from 40.74+/-2.50 to 61.19+/-2.64 (in percentiles). There was no significant treatment effect since this increase was similar in the control and the treatment groups (21.65+/-5.09 vs 19.14+/-3.67, respectively). However, there was a significant treatment effect (P<0.05) on the mean change in absolute number of lymphocytes during the 6-week study, which decreased in the control group (-0.04+/-0.12 cells x 10(3)/mm(3)) and increased in the treatment group (0.37+/-0.11 cells x 10(3)/mm(3)). There was also a significant treatment effect (P<0.05) on the change in absolute numbers of CD56 cells during the 6-week study. Mean absolute CD56 cells significantly decreased (P<0.05) in the control group (-51.97+/-21.33 cells/mm(3)),while remaining similar in the treatment group (17.29+/-17.27 cells/mm(3)). During the study, mean serum cortisol increased 4.30+/-0.98 microg/dL in the control group, and 1.75+/-1.05 microg/dL in the treatment group and no significant differences were found between both values (P=0.062).

conclusionsMilk fermented with yogurt cultures plus Lactobacillus casei DN-114001 was able to modulate the number of lymphocytes and CD56 cells in subjects under academic examination stress.

Indexed as

AdolescentAdultAnimalsAnxietyCD56 AntigenCultured Milk ProductsFemaleHumansHydrocortisoneImmunityLacticaseibacillus caseiLymphocyte CountMaleMilkCD56 AntigenHydrocortisone

Identifiers

PMID15309418
OpenAlexW1968880814

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.