ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2005
Accuracy of height loss during prospective monitoring for detection of incident vertebral fractures.
Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 3 of them syntheses that pooled it.
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Who cites it
50 citing papers in PubMed, 3 syntheses or guidelines pooled it, 159 citations in OpenAlex.
- Meta-analysis identifies a MECOM gene as a novel predisposing factor of osteoporotic fracture.Journal of medical genetics · 2013Pooled it
- Osteoporosis Canada 2010 guidelines for the assessment of fracture risk.Canadian Association of Radiologists journal = Journal l'Association canadienne des radiologistes · 2011Guideline
- Canadian Consensus Conference on osteoporosis, 2006 update.Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC · 2006Guideline
- Build better bones with exercise: protocol for a feasibility study of a multicenter randomized controlled trial of 12 months of home exercise in women with a vertebral fracture.Physical therapy · 2014Trial
- Intensive glycemic control is not associated with fractures or falls in the ACCORD randomized trial.Diabetes care · 2012Trial
- The role of physical performance measures in the physiotherapy assessment and management of older adults with osteoporotic vertebral fractures: a narrative review.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2025Review
- Association between Height-Changing Scores and Risk of Sarcopenia Estimated from Anthropometric Measurements in Older Adults: A Cross-Sectional Study.Healthcare (Basel, Switzerland) · 2024Article
- Age-Dependent Association of Height Loss with Incident Fracture Risk in Postmenopausal Korean Women.Endocrinology and metabolism (Seoul, Korea) · 2023Article
- Frailty and Aging in HIV- Status Post 13 Years of National Awareness.The Journal of frailty & aging · 2023Review
- Article
- Implications of historical height loss for prevalent vertebral fracture, spinal osteoarthritis, and gastroesophageal reflux disease.Scientific reports · 2020Article
- Adult spinal deformity and its relationship with height loss: a 34-year longitudinal cohort study.BMC musculoskeletal disorders · 2020Article
- Association of height loss with falls and sarcopenia in community-dwelling older women.Osteoporosis and sarcopenia · 2020Article
- Measured height loss predicts incident clinical fractures independently from FRAX: a registry-based cohort study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2020Article
- Impact of Vertebral Fractures and Glucocorticoid Exposure on Height Deficits in Children During Treatment of Leukemia.The Journal of clinical endocrinology and metabolism · 2019Article
- Risk factors for 5-year prospective height loss among postmenopausal women.Menopause (New York, N.Y.) · 2018Article
- Effects of discontinuing oral bisphosphonate treatments for postmenopausal osteoporosis on bone turnover markers and bone density.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2018Observational
- Is Retinal Microvascular Abnormalities an Independent Risk Factor of Vertebral Fractures? A Prospective Study From a Chinese Population.JBMR plus · 2017Article
- Inaccurate self-report of height and its impact on misclassification of body mass index in postmenopausal women.Menopause (New York, N.Y.) · 2017Observational
- Health-related Quality of Life in Accordance with Fracture History and Comorbidities in Korean Patients with Osteoporosis.Journal of bone metabolism · 2016Article
Corrections and comments
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Authors and funding
12 authors at 11 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vertebral fractures are the most common type of osteoporotic fracture, but more than two-thirds remain undetected. We have examined the relationship between height loss and the development of new vertebral fractures to determine whether there is a height loss threshold that has useful clinical accuracy to detect new fractures. We studied 985 postmenopausal women with osteoporosis in the placebo arms of the Vertebral Efficacy with Risedronate Therapy studies. Height was measured annually for 3 years using a wall-mounted stadiometer. New fractures were determined using quantitative and semi-quantitative radiographic morphometry. The relationship between height loss over three years and the number of new vertebral fractures was: height loss (cm) = 0.95 x number of new vertebral fractures-0.4 cm (r = 0.33). The odds ratio for the development of a new fracture increased up to 20.6 (95% confidence interval, 9.3, 45.8) when height loss was greater than 4.0 cm. At a threshold of > 2.0 cm height loss over 3 years, sensitivity was 35.5% for detecting new vertebral fractures and specificity was 93.6%. These findings show that there is a strong relationship between the amount of height loss and the risk of a new vertebral fracture. While there is no cut-off that can reliably rule in a new fracture, height loss of < or = 2.0 cm over 1-3 years has acceptable accuracy for ruling out an incident fracture.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.