ArticleThe Journal of physiology2004
Evidence that fast exocytosis can be predominantly mediated by vesicles not docked at active zones in frog saccular hair cells.
Article in The Journal of physiology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed, 84 citations in OpenAlex.
- Article
- Electrophysiological profiling of exocytosis during early-stage development of the zebrafish lateral line.bioRxiv : the preprint server for biology · 2025Article
- Review
- Signal transmission in mature mammalian vestibular hair cells.Frontiers in cellular neuroscience · 2022Article
- Resurgent NaNature communications · 2021Article
- Vesicle sub-pool organization at inner hair cell ribbon synapses.EMBO reports · 2018Article
- Synaptic Ribbons Require Ribeye for Electron Density, Proper Synaptic Localization, and Recruitment of Calcium Channels.Cell reports · 2016Article
- Relating structure and function of inner hair cell ribbon synapses.Cell and tissue research · 2015Review
- Single Ca2+ channels and exocytosis at sensory synapses.The Journal of physiology · 2013Review
- Disruption of the presynaptic cytomatrix protein bassoon degrades ribbon anchorage, multiquantal release, and sound encoding at the hair cell afferent synapse.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Neuromodulator-evoked synaptic metaplasticity within a central pattern generator network.Journal of neurophysiology · 2012Article
- Exocytosis in the frog amphibian papilla.Journal of the Association for Research in Otolaryngology : JARO · 2012Article
- Expression and localization of ryanodine receptors in the frog semicircular canal.Journal of biomedicine & biotechnology · 2012Article
- Sharp Ca²⁺ nanodomains beneath the ribbon promote highly synchronous multivesicular release at hair cell synapses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Article
- Recovery from short-term depression and facilitation is ultrafast and Ca2+ dependent at auditory hair cell synapses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Article
- The diverse roles of ribbon synapses in sensory neurotransmission.Nature reviews. Neuroscience · 2010Review
- Summing Across Different Active Zones can Explain the Quasi-Linear Ca-Dependencies of Exocytosis by Receptor Cells.Frontiers in synaptic neuroscience · 2010Article
- Vesicle pool size at the salamander cone ribbon synapse.Journal of neurophysiology · 2010Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The prevailing model of neurotransmitter release stipulates that Ca2+ influx triggers the rapid fusion of vesicles that are docked at presynaptic active zones. Under this model, slower tonic release is supported by vesicles clustered nearby that have to translocate to the release sites before fusion. We have examined this hypothesis at the afferent synapse of saccular hair cells of the leopard frog, Rana pipiens. Detailed morphological measurements at this ribbon synapse show that on average 32 vesicles are docked at each active zone. We show that at this 'graded' synapse, depolarization produces an exocytotic 'burst' that is largely complete within 20 ms after fusion of 280 vesicles per active zone, almost an order of magnitude more than expected. Recovery from paired pulse depression occurs with a time constant of 29 ms, indicating that replenishment of this fast-fusing pool of vesicles is also fast. Our results suggest that non-docked vesicles are capable of fast fusion and that these vesicles constitute the vast majority of the fast-fusing pool. The view that the population of fast-fusing presynaptic vesicles is limited to docked vesicles therefore requires re-evaluation. We propose that compound fusion, i.e. the fusion of vesicles with each other before and/or after they fuse with the membrane can explain multivesicular release at this synapse.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.