ArticleAnnals of the rheumatic diseases2004
Radiological sacroiliitis, a hallmark of spondylitis, is linked with CARD15 gene polymorphisms in patients with Crohn's disease.
Article in Annals of the rheumatic diseases, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 85 citations in OpenAlex.
- Red flags for appropriate referral to the gastroenterologist and the rheumatologist of patients with inflammatory bowel disease and spondyloarthritis.Clinical and experimental immunology · 2019Pooled it
- Metabolic musculoskeletal disorders in patients with inflammatory bowel disease.The Korean journal of internal medicine · 2025Review
- NOD2 and Crohn's Disease Clinical Practice: From Epidemiology to Diagnosis and Therapy, Rewired.Inflammatory bowel diseases · 2025Review
- Extraintestinal Manifestations in Inflammatory Bowel Disease: From Pathophysiology to Treatment.Biomedicines · 2024Review
- Extraintestinal Manifestations of Inflammatory Bowel Disease: Current Concepts, Treatment, and Implications for Disease Management.Gastroenterology · 2021Review
- [Update: enterogenic spondylarthritis].Zeitschrift fur Rheumatologie · 2021Article
- Prevalence of axial spondyloarthritis in patients with inflammatory bowel disease using cross-sectional imaging: a systematic literature review.Therapeutic advances in musculoskeletal disease · 2021Review
- Managing Psoriatic Arthritis With Inflammatory Bowel Disease and/or Uveitis.Frontiers in medicine · 2021Review
- Gut Microbiome and Its Interaction with Immune System in Spondyloarthritis.Microorganisms · 2020Review
- Etiopathogenesis of sacroiliitis: implications for assessment and management.The Korean journal of pain · 2020Review
- Pathogenesis and clinical perspectives of extraintestinal manifestations in inflammatory bowel diseases.Intestinal research · 2020Review
- Infliximab levels and antibodies in IBD-related peripheral arthralgia.International journal of colorectal disease · 2020Article
- Bidirectional Causal Associations Between Inflammatory Bowel Disease and Ankylosing Spondylitis: A Two-Sample Mendelian Randomization Analysis.Frontiers in genetics · 2020Article
- NOD2/CARD15 gene mutations in patients with gouty arthritis.Bosnian journal of basic medical sciences · 2016Article
- Prevalence and Characteristics of Extra-intestinal Manifestations in a Large Cohort of Greek Patients with Inflammatory Bowel Disease.Journal of Crohn's & colitis · 2016Article
- Occult spondyloarthritis in inflammatory bowel disease.Clinical rheumatology · 2016Review
- Current issues in pediatric inflammatory bowel disease-associated arthropathies.World journal of gastroenterology · 2014Review
- Extraintestinal manifestations and complications in IBD.Nature reviews. Gastroenterology & hepatology · 2013Review
- Ubiquitination and phosphorylation in the regulation of NOD2 signaling and NOD2-mediated disease.Biochimica et biophysica acta · 2012Review
- Rheumatological manifestations in inflammatory bowel disease.Annals of gastroenterology · 2011Review
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSacroiliitis is a common extraintestinal manifestation of Crohn's disease but its association with the HLA-B27 phenotype is less evident. Polymorphisms in the CARD15 gene have been linked to higher susceptibility for Crohn's disease. In particular, associations have been found with ileal and fibrostenosing disease, young age at onset of disease, and familial cases.
objectivesTo investigate whether the presence of sacroiliitis in patients with Crohn's disease is linked to the carriage of CARD15 polymorphisms.
methods102 consecutive patients with Crohn's disease were clinically evaluated by a rheumatologist. Radiographs of the sacroiliac joints were taken and assessed blindly by two investigators. The RFLP-PCR technique was used to genotype all patients for three single nucleotide polymorphisms (SNP) in the CARD15 gene. Every SNP was verified by direct sequencing. The HLA-B27 phenotype was determined.
resultsRadiological evidence of sacroiliitis with or without ankylosing spondylitis was found in 23 patients (23%), of whom only three were HLA-B27 positive. In contrast, 78% of patients with sacroiliitis carried a CARD15 variant v 48% of those without sacroiliitis (p = 0.01; odds ratio 3.8 (95% confidence interval, 1.3 to 11.5)). Multivariate analysis (logistic regression) showed that the association between sacroiliitis and CARD15 polymorphisms was independent of other CARD15 related phenotypes (ileal and fibrostenosing disease, young age at onset of disease, familial Crohn's disease) (p = 0.039).
conclusionsCARD15 variants were identified as genetic predictors of Crohn's disease related sacroiliitis. An association was demonstrated between these polymorphisms and an extraintestinal manifestation of Crohn's disease.
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