ArticleAnnals of the rheumatic diseases2004
Genetic risk of knee osteoarthritis: a sibling study.
Article in Annals of the rheumatic diseases, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 91 citations in OpenAlex.
- Pooled it
- Biological aspects of early osteoarthritis.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2012Pooled it
- Familial risks of five types of osteoarthritis in first-, second- and third-degree relatives - A nationwide Swedish family study.Osteoarthritis and cartilage open · 2025Article
- Family History of Arthritis, Osteoporosis, and Carpal Tunnel Syndrome and Risk of These Conditions Among US Adults.Arthritis care & research · 2024Article
- Improved genetic prediction of the risk of knee osteoarthritis using the risk factor-based polygenic score.Arthritis research & therapy · 2023Article
- Phenotype-Genotype analysis of caucasian patients with high risk of osteoarthritis.Frontiers in genetics · 2022Article
- Intraarticular STP Radiofrequency for Painful Osteoarthritis in the Knee: A Retrospective Single Center Analysis.Journal of pain research · 2021Article
- Arthritis and the role of endogenous glucocorticoids.Bone research · 2020Review
- Genome-wide association study of knee pain identifies associations withCommunications biology · 2019Article
- Longitudinal Growth and pQCT Measures in Hutterite Children and Grandchildren Are Associated With Prevalence of Hip or Knee Replacement Resulting From Osteoarthritis in Parents and Grandparents.Clinical orthopaedics and related research · 2018Article
- Whole exome sequencing in Finnish families identifies new candidate genes for osteoarthritis.PloS one · 2018Article
- Sex differences in risk and heritability estimates on primary knee osteoarthritis leading to total knee arthroplasty: a nationwide population based follow up study in Danish twins.Arthritis research & therapy · 2016Article
- Advances in osteoarthritis genetics.Journal of medical genetics · 2013Review
- The presence of MEFV gene mutations in patients with primary osteoarthritis who require surgery.The Korean journal of internal medicine · 2013Article
- A SMAD3 gene polymorphism is related with osteoarthritis in a Northeast Chinese population.Rheumatology international · 2013Article
- Association of a BMP5 microsatellite with knee osteoarthritis: case-control study.Arthritis research & therapy · 2012Article
- Identification of new susceptibility loci for osteoarthritis (arcOGEN): a genome-wide association study.Lancet (London, England) · 2012Article
- IL1B -511(G>A) and IL1RN (VNTR) allelic polymorphisms and susceptibility to knee osteoarthritis in Croatian population.Rheumatology international · 2012Article
- Genetic epidemiology of hip and knee osteoarthritis.Nature reviews. Rheumatology · 2011Review
- Computed tomography of subchondral bone and osteophytes in hip osteoarthritis: the shape of things to come?Frontiers in endocrinology · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo determine whether there is a genetic contribution to knee osteoarthritis (OA) as defined by structural change on plain radiographs.
designSibling study. Comparison of knee OA prevalence in the community with knee OA prevalence among siblings of index cases with knee OA. SUBJECTS: 490 knee OA index cases listed for total knee replacement and 737 of their siblings aged >40 years, 1729 community subjects aged >40 years.
main outcome measureOdds ratio for radiographic knee OA in siblings v community participants.
resultsThe age, sex, and knee pain adjusted odds ratios in siblings were 2.9 (95% confidence interval 2.3 to 3.7) for tibiofemoral OA and 1.7 (1.4 to 2.2) for patellofemoral OA. This difference remained after adjustment for important environmental risk factors. The heritability estimate for knee OA was 0.62.
conclusionsSiblings are at increased risk of knee OA in comparison with the general population. This is likely to be due to genetic factors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.