ReviewAmerican journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons2004
Xenotransplantation: infectious risk revisited.
Review in American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
53 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Free tendon grafts for surgical management of chronic tears of the main body of the Achilles tendon: a systematic review.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2023Pooled it
- Bibliometric analysis of liver xenotransplantation (2005-2025): trends, challenges and future directions.Updates in surgery · 2026Article
- First Molecular Detection of Porcine Cytomegalovirus (PCMV) and Porcine Lymphotropic Herpesvirus (PLHV) in Domestic Pigs in Poland.Pathogens (Basel, Switzerland) · 2025Article
- Surveillance and prevention of infection in clinical xenotransplantation.Clinical microbiology reviews · 2025Review
- Infectious Diseases and Clinical Xenotransplantation.Emerging infectious diseases · 2024Review
- Establishment of a male fertility prediction model with sperm RNA markers in pigs as a translational animal model.Journal of animal science and biotechnology · 2022Article
- Therapeutic and tectonic keratoplasty with simple cryopreserved remnants of donor corneas: an 11 year retrospective case series.Scientific reports · 2022Article
- Infection in xenotransplantation: opportunities and challenges.Current opinion in organ transplantation · 2019Review
- Genetically-engineered pigs as sources for clinical red blood cell transfusion: What pathobiological barriers need to be overcome?Blood reviews · 2019Review
- Three Years' Experience of a Novel Biosynthetic Cellulose Dressing in Burns.Advances in wound care · 2019Article
- Article
- Absence of interaction between porcine endogenous retrovirus and porcine cytomegalovirus in pig-to-baboon renal xenotransplantation in vivo.Xenotransplantation · 2018Article
- Why was PERV not transmitted during preclinical and clinical xenotransplantation trials and after inoculation of animals?Retrovirology · 2018Review
- Distribution of Porcine Cytomegalovirus in Infected Donor Pigs and in Baboon Recipients of Pig Heart Transplantation.Viruses · 2018Article
- Can Antiretroviral Drugs Be Used to Treat Porcine Endogenous Retrovirus (PERV) Infection after Xenotransplantation?Viruses · 2017Review
- Regulation of Clinical Xenotransplantation-Time for a Reappraisal.Transplantation · 2017Review
- Effective Detection of Porcine Cytomegalovirus Using Non-Invasively Taken Samples from Piglets.Viruses · 2017Article
- A comprehensive microbiological safety approach for agarose encapsulated porcine islets intended for clinical trials.Xenotransplantation · 2016Article
- The role of genetically engineered pigs in xenotransplantation research.The Journal of pathology · 2016Review
- Identification and Analysis of the Porcine MicroRNA in Porcine Cytomegalovirus-Infected Macrophages Using Deep Sequencing.PloS one · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Xenotransplantation is a possible solution for the shortage of tissues for human transplantation. Multiple hurdles exist to clinical xenotransplantation, including immunologic barriers, metabolic differences between pigs--the source species most commonly considered--and humans, and ethical concerns. Since clinical trials were first proposed almost 10 years ago, the degree of risk for infection transmitted from the xenograft donor to the recipient has been extensively investigated. A number of potential viral pathogens have been identified including porcine endogenous retrovirus (PERV), porcine cytomegalovirus (PCMV), and porcine lymphotropic herpesvirus (PLHV). Sensitive diagnostic assays have been developed for each virus. Human-tropic PERV are exogenous recombinants between PERV-A and PERV-C sequences and are present in only a subset of swine. Porcine cytomegalovirus can be excluded from herds of source animals by early weaning of piglets. In contrast, the risks associated with PLHV remain undefined. Microbiologic studies and assays for potential xenogeneic pathogens have furthered understanding of risks associated with xenotransplantation. Thus far, clinical xenotransplantation of pig tissues has not resulted in transmission of viral infection to humans; significant risks for disease transmission from swine to humans have not been confirmed. If immunologic hurdles can be overcome, it is reasonable to initiate carefully monitored clinical trials.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.