ArticleGenes and immunity2004
Sequence analysis of the mannose-binding lectin (MBL2) gene reveals a high degree of heterozygosity with evidence of selection.
Article in Genes and immunity, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
39 citing papers in PubMed, 91 citations in OpenAlex.
- Mannose-binding lectin gene sequence data in Kelantan population.Scientific data · 2024Article
- Rat microbial biogeography and age-dependent lactic acid bacteria in healthy lungs.Lab animal · 2024Article
- Association of mannose binding lectin with chronic obstructive pulmonary disease susceptibility and its clinical outcomes.Molecular biology reports · 2023Article
- Balancing selection on the complement system of a wild rodent.BMC ecology and evolution · 2023Article
- Mannose-binding lectin 2 gene polymorphisms and predisposition to allergic bronchial asthma in a western Romanian children population: an observational study.The Journal of international medical research · 2022Observational
- Tackling COVID-19 infection through complement-targeted immunotherapy.British journal of pharmacology · 2021Review
- The ambiguous role of mannose-binding lectin (MBL) in human immunity.Open medicine (Warsaw, Poland) · 2021Review
- Mannose-binding lectin gene polymorphisms in the East Siberia and Russian Arctic populations.Immunogenetics · 2020Article
- Exploring association between MBL2 gene polymorphisms and the occurrence of clinical blackwater fever through a case-control study in Congolese children.Malaria journal · 2020Article
- The association of mannose binding lectin genotype and immune response to Chlamydia pneumoniae: The Strong Heart Study.PloS one · 2019Article
- The Role of Complement Activating Collectins and Associated Serine Proteases in Patients With Hematological Malignancies, Receiving High-Dose Chemotherapy, and Autologous Hematopoietic Stem Cell Transplantations (Auto-HSCT).Frontiers in immunology · 2018Article
- Serum mannose-binding lectin concentration, but not genotype, is associated with Clostridium difficile infection recurrence: a prospective cohort study.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2014Article
- If there is an evolutionary selection pressure for the high frequency of MBL2 polymorphisms, what is it?Clinical and experimental immunology · 2014Review
- Mannose binding lectin and susceptibility to rheumatoid arthritis in Brazilian patients and their relatives.PloS one · 2014Article
- The lectin pathway of complement and rheumatic heart disease.Frontiers in pediatrics · 2014Review
- Extreme high prevalence of a defective mannose-binding lectin (MBL2) genotype in native South American West Andean populations.PloS one · 2014Article
- Population genetic tools for dissecting innate immunity in humans.Nature reviews. Immunology · 2013Review
- Lectin-dependent enhancement of Ebola virus infection via soluble and transmembrane C-type lectin receptors.PloS one · 2013Article
- Increased plasma mannose binding lectin levels are associated with bronchiolitis obliterans after lung transplantation.Respiratory research · 2012Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Human mannose-binding protein (MBL) is a component of innate immunity. To capture the common genetic variants of MBL2, we resequenced a 10.0 kb region that includes MBL2 in 102 individuals representing four major US ethnic groups. In all, 87 polymorphic sites were observed, indicating a high level of heterozygosity (total pi=18.3 x 10(-4)). Estimates of linkage disequilibrium across MBL2 indicate that it is divided into two blocks, with a probable recombination hot spot in the 3' end. Three non-synonymous SNPs in exon 1 of the encoding MBL2 gene and three upstream SNPs form common 'secretor haplotypes' that can predict circulating levels. Common variants have been associated with increased susceptibility to infection and autoimmune diseases. The high frequencies of B, C and D alleles in certain populations suggest a possible selective advantage for heterozygosity. There is limited diversity of haplotype structure; the 'secretor haplotypes' lie on a restricted number of extended haplotypes, which could include additional linked SNPs, which might also have possible functional implications. There is evidence for gene conversion in the region between the two blocks, in the last exon. Our data should form the basis for conducting MBL2 candidate gene association studies using a locus-wide approach.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.