ReviewJournal of thrombosis and thrombolysis2004
Evidence for C-reactive protein's role in (CRP) vascular disease: atherothrombosis, immuno-regulation and CRP.
Review in Journal of thrombosis and thrombolysis, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 74 citations in OpenAlex.
- Neighborhood Safety and Hypertension Risk: A Systematic Review.Journal of the American Heart Association · 2025Pooled it
- The impact of plasma high-sensitivity C-reactive protein levels on cardiovascular risk stratification of hypertensive patients: results of the ICEBERG study.Journal of clinical hypertension (Greenwich, Conn.) · 2007Trial
- Evaluating the clinical significance of tumor-expressed C-reactive protein in chromophobe renal cell carcinoma.Scientific reports · 2026Article
- Association of C-reactive protein-triglyceride glucose index with the incidence and mortality of cardiovascular disease: a retrospective cohort study.Cardiovascular diabetology · 2025Article
- The relation between C-reactive protein (CRP) and risk of incident heart failure in patients with cardiovascular disease: a narrative review.Annals of medicine and surgery (2012) · 2025Review
- A biobehavioral observational study to understand the multilevel determinants of cardiovascular health in Black women: the BLOOM Study protocol.BMC women's health · 2024Observational
- The Fabrication of a Probe-Integrated Electrochemiluminescence Aptasensor Based on Double-Layered Nanochannel Array with Opposite Charges for the Sensitive Determination of C-Reactive Protein.Molecules (Basel, Switzerland) · 2023Article
- Peripheral and Cerebral Vasodilation in Black and White Women: Examining the Impact of Psychosocial Stress Exposure Versus Internalization and Coping.Hypertension (Dallas, Tex. : 1979) · 2023Article
- Association between the increased level of high-sensitive CRP (hs CRP) and non-arrhythmic ECG changes and echocardiographic abnormalities in patients with acute coronary syndrome.Caspian journal of internal medicine · 2023Article
- A Simple Label-Free Aptamer-Based Electrochemical Biosensor for the Sensitive Detection of C-Reactive Proteins.Biosensors · 2022Article
- Recent Advances in CRP Biosensor Based on Electrical, Electrochemical and Optical Methods.Sensors (Basel, Switzerland) · 2021Review
- Increased Serum C-reactive Protein and Corpus Callosum Alterations in Older Adults.Aging and disease · 2019Article
- Body mass and white matter integrity: the influence of vascular and inflammatory markers.PloS one · 2013Article
- High-sensitivity C-reactive protein: an independent risk factor for left ventricular hypertrophy in patients with lupus nephritis.Journal of biomedicine & biotechnology · 2010Article
- Secondary prevention strategies for coronary heart disease.Journal of thrombosis and thrombolysis · 2010Review
- C-reactive protein and lipid profiles in Korean patients with normal tension glaucoma.Korean journal of ophthalmology : KJO · 2009Article
- Beyond platelet inhibition: potential pleiotropic effects of ADP-receptor antagonists.Journal of thrombosis and thrombolysis · 2009Review
- Interleukin-17 stimulates C-reactive protein expression in hepatocytes and smooth muscle cells via p38 MAPK and ERK1/2-dependent NF-kappaB and C/EBPbeta activation.The Journal of biological chemistry · 2007Article
- Is South Asian ethnicity an independent cardiovascular risk factor?The Canadian journal of cardiology · 2006Review
- Leptin, soluble interleukin-6 receptor, C-reactive protein and soluble vascular cell adhesion molecule-1 levels in human coronary atherosclerotic plaque.Clinical and experimental immunology · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
For clinicians plasma C-reactive protein (CRP) levels are the only widely available tests that provide a tangible link between inflammation and atherosclerosis. New AHA/CDC joint guidelines from 2002-03 now include the measurement of CRP as a class IIa recommendation for stratifying patients with known cardiovascular disease (CVD) at a moderate (10-20%) 10-year event risk and a class IIb recommendation for patients without known CVD [1]. While the association of CRP and atherosclerosis is by now accepted, the molecular biology behind the association is evolving rapidly into a fascinating story. While some of the story remains obscure, this review aims to bridge the clinical and basic science and identify what is known about the role of this ancient molecule in atherosclerosis. The review covers CRP's interaction with atherosclerosis' major ingredients and cell types including the endothelium, monocytes and neutrophils, lipoproteins and the complement system. Taken together, the clinical and basic science leave the tantalizing impression that CRP has a fundamental role in atherogenesis, and hint at a more complex immunomodulatory effect which transforms the acute inflammatory response to vascular injury into the chronic inflammation seen in atherosclerosis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.