ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2004
A conserved role but different partners for the transcriptional corepressor CoREST in fly and mammalian nervous system formation.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Insights into the transcriptomic responses of silver-lipped pearl oysters Pinctada maxima exposed to a simulated large-scale seismic survey.BMC genomics · 2024Article
- The CoREST complex regulates multiple histone modifications temporal-specifically in clock neurons.Open biology · 2024Article
- A developmental role for the chromatin-regulating CoREST complex in the cnidarian Nematostella vectensis.BMC biology · 2022Article
- Tramtrack acts during late pupal development to direct ant caste identity.PLoS genetics · 2021Article
- Rpd3/CoRest-mediated activity-dependent transcription regulates the flexibility in memory updating in Drosophila.Nature communications · 2021Article
- Constructing and Tuning Excitatory Cholinergic Synapses: The Multifaceted Functions of Nicotinic Acetylcholine Receptors inFrontiers in cellular neuroscience · 2021Review
- Epigenetic Regulator CoREST Controls Social Behavior in Ants.Molecular cell · 2020Article
- Distinct CoREST complexes act in a cell-type-specific manner.Nucleic acids research · 2019Article
- CoRest1 regulates neurogenesis in a stage-dependent manner.Developmental dynamics : an official publication of the American Association of Anatomists · 2019Article
- ETV5 is Essential for Neuronal Differentiation of Human Neural Progenitor Cells by Repressing NEUROG2 Expression.Stem cell reviews and reports · 2019Article
- A genetic screen and transcript profiling reveal a shared regulatory program for Drosophila linker histone H1 and chromatin remodeler CHD1.G3 (Bethesda, Md.) · 2015Article
- The progenitor state is maintained by lysine-specific demethylase 1-mediated epigenetic plasticity during Drosophila follicle cell development.Genes & development · 2014Article
- Chromatin regulation: how complex does it get?Epigenetics · 2014Review
- Differential properties of transcriptional complexes formed by the CoREST family.Molecular and cellular biology · 2014Article
- The insulator protein Suppressor of Hairy-wing is an essential transcriptional repressor in the Drosophila ovary.Development (Cambridge, England) · 2013Article
- Article
- Zebrafish rest regulates developmental gene expression but not neurogenesis.Development (Cambridge, England) · 2012Article
- Frequent recent origination of brain genes shaped the evolution of foraging behavior in Drosophila.Cell reports · 2012Article
- CoREST acts as a positive regulator of Notch signaling in the follicle cells of Drosophila melanogaster.Journal of cell science · 2012Article
- LINT, a novel dL(3)mbt-containing complex, represses malignant brain tumour signature genes.PLoS genetics · 2012Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Identification of conserved proteins that act to establish the neuronal phenotype has relied predominantly on structural homologies of the underlying genes. In the case of the repressor element 1 silencing transcription factor (REST), a central player in blocking the neuronal phenotype in vertebrate non-neural tissue, the invertebrate homolog is absent, raising the possibility that distinct strategies are used to establish the CNS of invertebrates. Using a yeast two-hybrid screen designed specifically to identify functional analogs of REST, we show that Drosophila melanogaster uses a strategy that is functionally similar to, but appears to have evolved independently of, REST. The gene at the center of the strategy in flies encodes the repressor Tramtrack88 (Ttk88), a protein with no discernable homology to REST but that nonetheless is able to interact with the same transcriptional partners. Ttk88 uses the REST corepressor Drosophila CoREST to coordinately regulate a set of genes encoding the same neuronal hallmarks that are regulated by REST in vertebrates. Our findings indicate that repression is an important mechanism for regulating neuronal phenotype across phyla and suggest that co-option of a similar corepressor complex occurred to restrict expression of genes critical for neuronal function to a compartmentalized nervous system.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.