ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2004
Selective gene expression in magnocellular neurons in rat supraoptic nucleus.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 37 citations in OpenAlex.
- Article
- Mapping Molecular Datasets Back to the Brain Regions They are Extracted from: Remembering the Native Countries of Hypothalamic Expatriates and Refugees.Advances in neurobiology · 2018Article
- RNA binding protein Caprin-2 is a pivotal regulator of the central osmotic defense response.eLife · 2015Article
- A comparison of physiological and transcriptome responses to water deprivation and salt loading in the rat supraoptic nucleus.American journal of physiology. Regulatory, integrative and comparative physiology · 2015Article
- A RNA-Seq Analysis of the Rat Supraoptic Nucleus Transcriptome: Effects of Salt Loading on Gene Expression.PloS one · 2015Article
- Article
- The hypothalamic-neurohypophyseal system: from genome to physiology.Journal of neuroendocrinology · 2012Review
- Cell-type specific expression of oxytocin and vasopressin genes: an experimental odyssey.Journal of neuroendocrinology · 2012Review
- Long-lasting molecular changes in human skin after repetitive in situ UV irradiation.The Journal of investigative dermatology · 2009Article
- NMDA receptor subunit expression in GABAergic interneurons in the prefrontal cortex: application of laser microdissection technique.Journal of neuroscience methods · 2009Article
- Experimental approaches for the study of oxytocin and vasopressin gene expression in the central nervous system.Progress in brain research · 2008Article
- Characterisation of insulin-resistant phenotype of cultured rat primary adipose cells.Diabetologia · 2007Article
- Depolarization and neurotransmitter regulation of vasopressin gene expression in the rat suprachiasmatic nucleus in vitro.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- Dihydropyridine receptors and type 1 ryanodine receptors constitute the molecular machinery for voltage-induced Ca2+ release in nerve terminals.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- Sorting of Pmel17 to melanosomes through the plasma membrane by AP1 and AP2: evidence for the polarized nature of melanocytes.Journal of cell science · 2006Article
- Molecular analysis of the magnocellular neuroendocrine phenotype: from the micropunch to laser microdissection.Neurochemical research · 2006Article
- A comprehensive description of the transcriptome of the hypothalamoneurohypophyseal system in euhydrated and dehydrated rats.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Microarray analysis of gene expression in the supraoptic nucleus of normoosmotic and hypoosmotic rats.Cellular and molecular neurobiologyArticle
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
Oxytocin- and vasopressin-producing magnocellular neurons (MCNs) of the hypothalamo-neurohypophysial system are the only neuronal phenotypes present in the rat supraoptic nucleus (SON). Laser microdissection of the SON, extraction and T7-based amplification of its RNAs, and analysis of the resulting cDNAs by hybridization on a 35, 319 element DNA microarray have provided a detailed composite view of the gene expression profile of the MCNs. The genes expressed in the SON were compared with those expressed in a reference tissue consisting of total hypothalamus, and this "expression ratio" indicated which genes were preferentially expressed in the SON. Of the 26,000 unique genes on the array, 1385 were found to be expressed in the SON at levels more than two times greater than in the hypothalamus as a whole. Of these, 123 were expressed > or =3.4-fold higher in the SON versus hypothalamus. Most of these preferentially expressed genes were not previously known to be expressed in the MCNs. Quantitative and double-label in situ hybridization histochemistry was used selectively to confirm a number of these microarray observations and to evaluate the osmotic regulation and cell-specific expression of these genes, respectively.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.