ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2004
A role of ath5 in inducing neuroD and the photoreceptor pathway.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- A genome-wide association study of optic disc parameters.PLoS genetics · 2010Pooled it
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- Recapitulating developmental mechanisms for retinal regeneration.Progress in retinal and eye research · 2020Review
- Elevated expression of human bHLH factor ATOH7 accelerates cell cycle progression of progenitors and enhances production of avian retinal ganglion cells.Scientific reports · 2018Article
- De novo neurogenesis by targeted expression of atoh7 to Müller glia cells.Development (Cambridge, England) · 2016Article
- Zebrafish Lbh-like Is Required for Otx2-mediated Photoreceptor Differentiation.International journal of biological sciences · 2015Article
- Insulinoma-associated 1a (Insm1a) is required for photoreceptor differentiation in the zebrafish retina.Developmental biology · 2013Article
- A regulatory domain is required for Foxn4 activity during retinogenesis.Journal of molecular neuroscience : MN · 2012Article
- MiR-124 regulates early neurogenesis in the optic vesicle and forebrain, targeting NeuroD1.Nucleic acids research · 2011Article
- Pro-photoreceptor activity of chick neurogenin1.Investigative ophthalmology & visual science · 2009Article
- Reprogramming retinal pigment epithelium to differentiate toward retinal neurons with Sox2.Stem cells (Dayton, Ohio) · 2009Article
- Neurogenin3 promotes early retinal neurogenesis.Molecular and cellular neurosciences · 2009Article
- A comprehensive negative regulatory program controlled by Brn3b to ensure ganglion cell specification from multipotential retinal precursors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- The final fates of neurogenin2-expressing cells include all major neuron types in the mouse retina.Molecular and cellular neurosciences · 2006Article
- Pea3 expression is regulated by FGF signaling in developing retina.Developmental dynamics : an official publication of the American Association of Anatomists · 2006Article
- Influences on neural lineage and mode of division in the zebrafish retina in vivo.The Journal of cell biology · 2005Article
- bHLH genes and retinal cell fate specification.Molecular neurobiology · 2005Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Photoreceptors in the vertebrate retina are light-sensitive neurons, and their degeneration results in irreversible visual loss. Understanding how photoreceptor fate is determined is a prerequisite for developing photoreceptor replacement therapies. Previous studies identified two basic helix-loop-helix genes, neurogenin2 (ngn2) and neuroD, participating in a genetic pathway leading to photoreceptor genesis. Here we present experimental data suggesting that ath5, which is known for its critical role in retinal ganglion cell development, may also lead to photoreceptor production. In the developing retina, ath5 expression was detected in two zones of cells, and coexpression with neuroD was observed in the zone adjacent to young photoreceptor cells accumulating on the retinal pigment epithelial side. Retroviral-driven misexpression of ath5 in retinal cells increased the population of photoreceptor cells, as well as ganglion cells, in a developmental stage-dependent manner that is consistent with ath5 being involved in the development of multiple types of retinal neurons. Ectopic ath5 expression in cultures of non-neural retinal pigment epithelial cells elicited transdifferentiation into cells that expressed photoreceptor-specific genes and displayed photoreceptor-like morphologies. Gene expression analysis showed that ngn2 did not induce ath5, and ath5 did not induce ngn2, but both induced neuroD and RaxL. These data suggest a pathway of "ath5 --> neuroD --> photoreceptor genes" separate from yet convergent with the ngn2 pathway.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.