ReviewPhilosophical transactions of the Royal Society of London. Series B, Biological sciences2004
Nitric oxide control of cardiac function: is neuronal nitric oxide synthase a key component?
Review in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 82 citations in OpenAlex.
- Nitric oxide and regulation of heart rate in patients with postural tachycardia syndrome and healthy subjects.Hypertension (Dallas, Tex. : 1979) · 2013Trial
- Neuronal nitric oxide synthase control mechanisms in the cutaneous vasculature of humans in vivo.The Journal of physiology · 2008Trial
- MicroRNA-21-5p acts via the PTEN/Akt/FOXO3a signaling pathway to prevent cardiomyocyte injury caused by high glucose/high fat conditions.Experimental and therapeutic medicine · 2022Article
- Nitric oxide modulates cardiomyocyte pH control through a biphasic effect on sodium/hydrogen exchanger-1.Cardiovascular research · 2020Article
- Role of neuronal nitric oxide synthase on cardiovascular functions in physiological and pathophysiological states.Nitric oxide : biology and chemistry · 2020Review
- Chronic aerobic exercise associated to low-dose L-NAME improves contractility without changing calcium handling in rat cardiomyocytes.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2020Article
- Role of Nitric Oxide in the Cardiovascular and Renal Systems.International journal of molecular sciences · 2018Review
- Protective effect of N-acetylcysteine activated carbon release microcapsule on myocardial ischemia-reperfusion injury in rats.Experimental and therapeutic medicine · 2018Article
- The role of reactive oxygen species in myocardial redox signaling and regulation.Annals of translational medicine · 2017Review
- The role of S-nitrosoglutathione reductase (GSNOR) in human disease and therapy.Critical reviews in biochemistry and molecular biology · 2017Review
- Novel Perspectives in Redox Biology and Pathophysiology of Failing Myocytes: Modulation of the Intramyocardial Redox Milieu for Therapeutic Interventions-A Review Article from the Working Group of Cardiac Cell Biology, Italian Society of Cardiology.Oxidative medicine and cellular longevity · 2016Review
- Nitrosative modifications of the Ca2+ release complex and actin underlie arthritis-induced muscle weakness.Annals of the rheumatic diseases · 2015Article
- Plasma membrane calcium pump (PMCA4)-neuronal nitric-oxide synthase complex regulates cardiac contractility through modulation of a compartmentalized cyclic nucleotide microdomain.The Journal of biological chemistry · 2011Article
- Distribution of NADPH-diaphorase and AChE activity in the anterior leaflet of rat mitral valve.European journal of histochemistry : EJH · 2010Article
- Phospholamban S-nitrosylation modulates Starling response in fish heart.Proceedings. Biological sciences · 2009Article
- The exercising heart at altitude.Cellular and molecular life sciences : CMLS · 2009Review
- The heart is an early target of anthrax lethal toxin in mice: a protective role for neuronal nitric oxide synthase (nNOS).PLoS pathogens · 2009Article
- Physiological implications of the interaction between the plasma membrane calcium pump and nNOS.Pflugers Archiv : European journal of physiology · 2009Review
- Cardiac cholinergic NO-cGMP signaling following acute myocardial infarction and nNOS gene transfer.American journal of physiology. Heart and circulatory physiology · 2008Article
- Neuronal nitric oxide synthase immunopositive neurons in cat claustrum--a light and electron microscopic study.Journal of molecular histology · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nitric oxide (NO) has been shown to regulate cardiac function, both in physiological conditions and in disease states. However, several aspects of NO signalling in the myocardium remain poorly understood. It is becoming increasingly apparent that the disparate functions ascribed to NO result from its generation by different isoforms of the NO synthase (NOS) enzyme, the varying subcellular localization and regulation of NOS isoforms and their effector proteins. Some apparently contrasting findings may have arisen from the use of non-isoform-specific inhibitors of NOS, and from the assumption that NO donors may be able to mimic the actions of endogenously produced NO. In recent years an at least partial explanation for some of the disagreements, although by no means all, may be found from studies that have focused on the role of the neuronal NOS (nNOS) isoform. These data have shown a key role for nNOS in the control of basal and adrenergically stimulated cardiac contractility and in the autonomic control of heart rate. Whether or not the role of nNOS carries implications for cardiovascular disease remains an intriguing possibility requiring future study.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.