ReviewPhilosophical transactions of the Royal Society of London. Series B, Biological sciences2004
The N-methyl D-aspartate receptor glycine site and D-serine metabolism: an evolutionary perspective.
Review in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 95 citations in OpenAlex.
- D-Aspartate Depletion Perturbs Steroidogenesis and Spermatogenesis in Mice.Biomolecules · 2023Article
- Association of the D-amino acid oxidase gene with methadone dose in heroin dependent patients under methadone maintenance treatment.Journal of human genetics · 2022Article
- Gut Microbial Dysbiosis and Cognitive Impairment in Bipolar Disorder: Current Evidence.Frontiers in pharmacology · 2022Review
- Modulation of Hippocampal Astroglial Activity by Synaptamide in Rats with Neuropathic Pain.Brain sciences · 2021Article
- Human Serine Racemase: Key Residues/Active Site Motifs and Their Relation to Enzyme Function.Frontiers in molecular biosciences · 2019Review
- Monitoring hippocampal glycine with the computationally designed optical sensor GlyFS.Nature chemical biology · 2018Article
- Article
- Alterations in amino acid levels in mouse brain regions after adjunctive treatment of brexpiprazole with fluoxetine: comparison with (R)-ketamine.Psychopharmacology · 2017Article
- d-Amino Acid Levels in Perfused Mouse Brain Tissue and Blood: A Comparative Study.ACS chemical neuroscience · 2017Article
- Clinical and biochemical study of d-serine metabolism among schizophrenia patients.Neuropsychiatric disease and treatment · 2017Article
- D-serine in the midbrain periaqueductal gray contributes to morphine tolerance in rats.Molecular pain · 2016Article
- Haplotypes of the D-Amino Acid Oxidase Gene Are Significantly Associated with Schizophrenia and Its Neurocognitive Deficits.PloS one · 2016Article
- Effects of D-amino acid oxidase inhibition on memory performance and long-term potentiation in vivo.Pharmacology research & perspectives · 2013Article
- TRPA1 channels are regulators of astrocyte basal calcium levels and long-term potentiation via constitutive D-serine release.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- The DAO gene is associated with schizophrenia and interacts with other genes in the Taiwan Han Chinese population.PloS one · 2013Article
- AMPA receptor-dependent, light-evoked D-serine release acts on retinal ganglion cell NMDA receptors.Journal of neurophysiology · 2012Article
- D-Serine: a key to synaptic plasticity?The international journal of biochemistry & cell biology · 2012Review
- Serine hydroxymethyltransferase 1 and 2: gene sequence variation and functional genomic characterization.Journal of neurochemistry · 2012Article
- Role of serine racemase in behavioral sensitization in mice after repeated administration of methamphetamine.PloS one · 2012Article
- Crystal structure of a zinc-dependent D-serine dehydratase from chicken kidney.The Journal of biological chemistry · 2011Article
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Authors and funding
1 author at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
The N-methyl D-aspartate (NMDA) type of glutamate receptor requires two distinct agonists to operate. Glycine is assumed to be the endogenous ligand for the NMDA receptor glycine site, but this notion has been challenged by the discovery of high levels of endogenous d-serine in the mammalian forebrain. I have outlined an evolutionary framework for the appearance of a glycine site in animals and the metabolic events leading to high levels of D-serine in brain. Sequence alignments of the glycine-binding regions, along with the scant experimental data available, suggest that the properties of invertebrate NMDA receptor glycine sites are probably different from those in vertebrates. The synthesis of D-serine in brain is due to a pyridoxal-5'-phosphate (B(6))-requiring serine racemase in glia. Although it remains unknown when serine racemase first evolved, data concerning the evolution of B(6) enzymes, along with the known occurrences of serine racemases in animals, point to D-serine synthesis arising around the divergence time of arthropods. D-Serine catabolism occurs via the ancient peroxisomal enzyme d-amino acid oxidase (DAO), whose ontogenetic expression in the hindbrain of mammals is delayed until the postnatal period and absent from the forebrain. The phylogeny of D-serine metabolism has relevance to our understanding of brain ontogeny, schizophrenia and neurotransmitter dynamics.
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