ReviewPhilosophical transactions of the Royal Society of London. Series B, Biological sciences2004
Life at low water activity.
Review in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 107 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
107 citing papers in PubMed.
- From Heritage to Innovation: A Review of the Safety and Production of Aminopeptide Seasonings.Comprehensive reviews in food science and food safety · 2026Review
- Methane Production on Mars-Relevant Clay Minerals and Simulant Regolith.Microorganisms · 2026Article
- Article
- Bacterioruberin (CNutrients · 2025Review
- The effects of brines relevant to Mars and the ocean worlds on bacterial growth reflect salt-specific responses across water activity.Archives of microbiology · 2025Article
- Biotechnological potential of salt tolerant and xerophilic species of Aspergillus.Applied microbiology and biotechnology · 2024Review
- Microbial Life in Playa-Lake Sediments: Adapted Structure, Plastic Function to Extreme Water Activity Variations.Microbial ecology · 2024Article
- Halocins and CMarine drugs · 2024Review
- A TrmBL2-like transcription factor mediates the growth phase-dependent expression of halolysin SptA in a concentration-dependent manner inApplied and environmental microbiology · 2024Article
- Wood-Ljungdahl pathway encoding anaerobes facilitate low-cost primary production in hypersaline sediments at Great Salt Lake, Utah.FEMS microbiology ecology · 2024Article
- Risk-Based Approach for Defining Retest Dates for Active Pharmaceutical Ingredients and Excipients.Pharmaceuticals (Basel, Switzerland) · 2024Review
- HtrAs are essential for the survival of the haloarchaeonApplied and environmental microbiology · 2024Article
- Radioactive waste microbiology: predicting microbial survival and activity in changing extreme environments.FEMS microbiology reviews · 2024Review
- Microbial communities in the Dead Sea and their potential biotechnological applications.Communicative & integrative biology · 2024Review
- Single-cell analysis in hypersaline brines predicts a water-activity limit of microbial anabolic activity.Science advances · 2023Article
- Soil Thermophiles and Their Extracellular Enzymes: A Set of Capabilities Able to Provide Significant Services and Risks.Microorganisms · 2023Review
- Article
- The waterbodies of the halo-volcanic Dallol complex: earth analogs to guide us, where to look for life in the universe.Frontiers in microbiology · 2023Article
- Bioactive molecules from haloarchaea: Scope and prospects for industrial and therapeutic applications.Frontiers in microbiology · 2023Review
- The Osmoprotectant Switch of Potassium to Compatible Solutes in an Extremely Halophilic ArchaeaGenes · 2022Article
47 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Two major types of environment provide habitats for the most xerophilic organisms known: foods preserved by some form of dehydration or enhanced sugar levels, and hypersaline sites where water availability is limited by a high concentration of salts (usually NaCl). These environments are essentially microbial habitats, with high-sugar foods being dominated by xerophilic (sometimes called osmophilic) filamentous fungi and yeasts, some of which are capable of growth at a water activity (a(w)) of 0.61, the lowest a(w) value for growth recorded to date. By contrast, high-salt environments are almost exclusively populated by prokaryotes, notably the haloarchaea, capable of growing in saturated NaCl (a(w) 0.75). Different strategies are employed for combating the osmotic stress imposed by high levels of solutes in the environment. Eukaryotes and most prokaryotes synthesize or accumulate organic so-called 'compatible solutes' (osmolytes) that have counterbalancing osmotic potential. A restricted range of bacteria and the haloarchaea counterbalance osmotic stress imposed by NaCl by accumulating equivalent amounts of KCl. Haloarchaea become entrapped and survive for long periods inside halite (NaCl) crystals. They are also found in ancient subterranean halite (NaCl) deposits, leading to speculation about survival over geological time periods.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.