ArticleEuropean journal of clinical nutrition2004
Effect of acute oral calcium load on serum PTH and bone resorption in young healthy subjects: an overnight study.
Article in European journal of clinical nutrition, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 27 citations in OpenAlex.
- Effects of two marine dietary supplements with high calcium content on calcium metabolism and biochemical marker of bone resorption.European journal of clinical nutrition · 2008Trial
- Calcium deficiency and its implications for cardiovascular disease and cancer: Strategies for resolution via agronomic fortification.Food science & nutrition · 2024Review
- Disruption of the c-terminal serine protease domain of Fam111a does not alter calcium homeostasis in mice.Physiological reports · 2024Article
- How useful is an oral calcium load test for diagnosing recurrent calcium stone formers?Urolithiasis · 2022Article
- Calcium deficiency worldwide: prevalence of inadequate intakes and associated health outcomes.Annals of the New York Academy of Sciences · 2022Article
- The role of calcium-sensing receptor signaling in regulating transepithelial calcium transport.Experimental biology and medicine (Maywood, N.J.) · 2021Review
- Mechanisms Involved in the Relationship between Low Calcium Intake and High Blood Pressure.Nutrients · 2019Review
- Postprandial metabolic responses of serum calcium, parathyroid hormone and C-telopeptide of type I collagen to three doses of calcium delivered in milk.Journal of nutritional science · 2014Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate the effects of a 400 mg acute oral calcium dose on PTH and bone resorption markers in a young, healthy population.
designFasting serum parathyroid hormone (PTH), C-telopeptides (CTX), total calcium (Ca), albumin and urinary calcium/creatinine ratio (uCa/Cr) were measured on two separate days: one before and the other 10 h after oral administration of 400 mg calcium. Serum 25-hydroxy vitamin D (25-OHD) status was assessed at baseline. Dietary calcium intake was assessed using a food frequency questionnaire (FFQ). SUBJECTS: A total of 32 healthy, young adults (17 female, 15 male; mean+/-s.e.m. age: 21+/-1 y) took part in this study. Their mean (s.e.m.) calcium intake was 1125 (+/-56) mg/day.
interventionEffervescent Sandocal 400 tablets dissolved in water.
resultsAfter the calcium challenge, mean Ca and uCa/Cr ratio increased significantly, and both PTH and CTX concentrations were significantly lower. Multiple regression analysis showed no relationship between the response to the 400 mg load and previous dietary calcium intake (as assessed by FFQ) or serum 25-OHD.
conclusionWe have shown that in a young, healthy population, 400 mg oral calcium can inhibit bone resorption (as measured by serum CTX) and PTH, and this appears to be independent of previous dietary calcium intake and vitamin D status.
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