ArticleProceedings of the National Academy of Sciences of the United States of America2004
The T cell antigen receptor expressed by Valpha14i NKT cells has a unique mode of glycosphingolipid antigen recognition.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed, 96 citations in OpenAlex.
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- Natural and synthetic carbohydrate-based vaccine adjuvants and their mechanisms of action.Nature reviews. Chemistry · 2021Review
- Polar functional group-containing glycolipid CD1d ligands modulate cytokine-biasing responses and prevent experimental colitis.Scientific reports · 2020Article
- 4"-O-Alkylated α-Galactosylceramide Analogues as iNKT-Cell Antigens: Synthetic, Biological, and Structural Studies.ChemMedChem · 2019Article
- Photoactivable Glycolipid Antigens Generate Stable Conjugates with CD1d for Invariant Natural Killer T Cell Activation.Bioconjugate chemistry · 2018Article
- Dual Modifications of α-Galactosylceramide Synergize to Promote Activation of Human Invariant Natural Killer T Cells and Stimulate Anti-tumor Immunity.Cell chemical biology · 2018Article
- The Role of Natural Killer T Cells in Cancer-A Phenotypical and Functional Approach.Frontiers in immunology · 2018Review
- Are fat NKT cells born that way?Cellular & molecular immunology · 2017Article
- TCRα-TCRβ pairing controls recognition of CD1d and directs the development of adipose NKT cells.Nature immunology · 2017Article
- A Novel Glycolipid Antigen for NKT Cells That Preferentially Induces IFN-γ Production.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- The Alpha and Omega of Galactosylceramides in T Cell Immune Function.The Journal of biological chemistry · 2015Review
- Relationships between Th1 or Th2 iNKT cell activity and structures of CD1d-antigen complexes: meta-analysis of CD1d-glycolipids dynamics simulations.PLoS computational biology · 2014Article
- Synthesis of a 2"-deoxy-β-GalCer.Molecules (Basel, Switzerland) · 2014Article
- Raising the roof: the preferential pharmacological stimulation of Th1 and th2 responses mediated by NKT cells.Medicinal research reviews · 2014Review
- Molecular basis of lipid antigen presentation by CD1d and recognition by natural killer T cells.Immunological reviews · 2012Review
- T cells specific for lipid antigens.Immunologic research · 2012Review
- Interplay between carbohydrate and lipid in recognition of glycolipid antigens by natural killer T cells.Annals of the New York Academy of Sciences · 2012Review
- Glycolipids that elicit IFN-γ-biased responses from natural killer T cells.Chemistry & biology · 2011Article
- Unique interplay between sugar and lipid in determining the antigenic potency of bacterial antigens for NKT cells.PLoS biology · 2011Article
- Invariant natural killer T cells recognize glycolipids from pathogenic Gram-positive bacteria.Nature immunology · 2011Article
Corrections and comments
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
Abstract
Natural killer (NK) T cells with an invariant Valpha14 rearrangement (Valpha14i) are the largest population of lipid antigen-specific T lymphocytes identified in animals. They react to the glycolipid alpha-galactosyl ceramide (alpha-GalCer) presented by CD1d, and they may have important regulatory functions. It was previously shown that the Valpha14i T cell antigen receptor (TCR) has a high affinity for the alpha-GalCer/CD1d complex, driven by a long half-life (t(1/2)). Although this result could have reflected the unique attributes of alpha-GalCer, using several related glycolipid compounds, we show here that the threshold for full activation of Valpha14i NKT cells by these glycosphingolipids requires a relatively high-affinity TCR interaction with a long t(1/2). Furthermore, our data are consistent with the view that the mechanism of recognition of these compounds presented by CD1d to the Valpha14i NKT cell TCR is likely to fit a lock-and-key model. Overall, these findings emphasize the distinct properties of glycosphingolipid antigen recognition by Valpha14i NKT cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.