ArticleBMC infectious diseases2004
Epidemiological evidence of higher susceptibility to vCJD in the young.
Article in BMC infectious diseases, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Risk of transmission of sporadic Creutzfeldt-Jakob disease by surgical procedures: systematic reviews and quality of evidence.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2017Pooled it
- A review of the enhanced CJD surveillance feasibility study in the elderly in Scotland, UK.BMC geriatrics · 2024Review
- Variant CJD: Reflections a Quarter of a Century on.Pathogens (Basel, Switzerland) · 2021Review
- Distinct α-Synuclein strains and implications for heterogeneity among α-Synucleinopathies.Neurobiology of disease · 2018Review
- How do PrPPathogens (Basel, Switzerland) · 2017Review
- Increased Abundance of M Cells in the Gut Epithelium Dramatically Enhances Oral Prion Disease Susceptibility.PLoS pathogens · 2016Article
- Article
- Drivers: A Biologically Contextualized, Cross-Inferential View of the Epidemiology of Neurodegenerative Disorders.Journal of Alzheimer's disease : JAD · 2016Article
- Recent US Case of Variant Creutzfeldt-Jakob Disease-Global Implications.Emerging infectious diseases · 2015Article
- Towards an age-dependent transmission model of acquired and sporadic Creutzfeldt-Jakob disease.PloS one · 2014Article
- Susceptibility of young sheep to oral infection with bovine spongiform encephalopathy decreases significantly after weaning.Journal of virology · 2012Article
- The effects of host age on the transport of complement-bound complexes to the spleen and the pathogenesis of intravenous scrapie infection.Journal of virology · 2012Article
- Repetitive immunization enhances the susceptibility of mice to peripherally administered prions.PloS one · 2009Article
- Introduction: conceptualizing and partitioning the emergence process of zoonotic viruses from wildlife to humans.Current topics in microbiology and immunology · 2007Review
- Heterogeneous shedding of Escherichia coli O157 in cattle and its implications for control.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Comparative evidence for a link between Peyer's patch development and susceptibility to transmissible spongiform encephalopathies.BMC infectious diseases · 2006Article
- New approaches to quantifying the spread of infection.Nature reviews. Microbiology · 2005Review
- High incidence of scrapie induced by repeated injections of subinfectious prion doses.Journal of virology · 2005Article
- Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe strikingly young age of new variant Creutzfeldt-Jacob disease (vCJD) cases remains unexplained. Age dependent susceptibility to infection has been put forward, but differential dietary exposure to contaminated food products in the UK population according to age and sex during the bovine spongiform encephalopathy (BSE) epidemic may provide a simpler explanation.
methodsUsing recently published estimates of dietary exposure in mathematical models of the epidemiology of the new variant Creutzfeldt Jacob disease (vCJD), we examine whether the age characteristics of vCJD cases may be reproduced.
resultsThe susceptibility/exposure risk function has likely peaked in adolescents and was followed by a sharp decrease with age, evocative of the profile of exposure to bovine material consumption according to age. However, assuming that the risk of contamination was proportional to exposure, with no age dependent susceptibility, the model failed to reproduce the observed age characteristics of the vCJD cases: The predicted cumulated proportion of cases over 40 years was 48%, in strong disagreement with the observed 10%. Incorporating age dependent susceptibility led to a cumulated proportion of cases over 40 years old of 12%.
conclusionsThis analysis provides evidence that differential dietary exposure alone fails to explain the pattern of age in vCJD cases. Decreasing age related susceptibility is required to reproduce the characteristics of the age distribution of vCJD cases.
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