ReviewLupus2004
T-lymphocyte signalling in systemic lupus erythematosus: a lipid raft perspective.
Review in Lupus, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 27 citations in OpenAlex.
- From Genes to Pathways: The Molecular Landscape of Systemic Lupus Erythematosus.International journal of molecular sciences · 2026Review
- Pre-organized landscape of T cell surface.Frontiers in immunology · 2023Review
- Article
- Review
- Lysosomal targeting and trafficking of acid sphingomyelinase to lipid raft platforms in coronary endothelial cells.Arteriosclerosis, thrombosis, and vascular biology · 2008Article
- Critical role of lipid raft redox signaling platforms in endostatin-induced coronary endothelial dysfunction.Arteriosclerosis, thrombosis, and vascular biology · 2008Article
- Agrin signalling contributes to cell activation and is overexpressed in T lymphocytes from lupus patients.Journal of immunology (Baltimore, Md. : 1950) · 2007Article
- Altered dynamics of Kv1.3 channel compartmentalization in the immunological synapse in systemic lupus erythematosus.Journal of immunology (Baltimore, Md. : 1950) · 2007Article
- CD134 expression on CD4+ T cells is associated with nephritis and disease activity in patients with systemic lupus erythematosus.Clinical and experimental immunology · 2006Article
- Regulation of T-cell receptor signalling by membrane microdomains.Immunology · 2004Review
- Lipid rafts in T cell receptor signalling .Molecular membrane biologyReview
- The role of nitric oxide in abnormal T cell signal transduction in systemic lupus erythematosus.Clinical immunology (Orlando, Fla.)Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
In the last few years it has become clear that in cells of the immune system, specialized microdomains present in the plasma membrane, called lipid rafts, have been found to play a central role in regulating signalling by immune receptors. Recent studies have looked at whether lipid rafts may be connected to the abnormalities in signalling seen in T lymphocytes isolated from patients with systemic lupus erythematosus (SLE). These early findings show that in SLE T cells, the expression and protein composition of lipid rafts is different when compared with normal T cells. These results also demonstrate changes in the function and localization of critical signalling molecules such as the LCK tyrosine kinase and the CD45 tyrosine phosphatase.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.