ArticleJournal of inherited metabolic disease2004
Effect of high-dose vitamins, coenzyme Q and high-fat diet in paediatric patients with mitochondrial diseases.
Article in Journal of inherited metabolic disease, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04543968 (Open Label Pilot Study Using Hydroxytyrosol), which is not on this map. Cited by 14 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Open Label Pilot Study Using Hydroxytyrosol (HT) as a Dietary Supplement in Patients With Mitochondrial Diseases (MDs)
Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 45 citations in OpenAlex.
- Effectiveness of Riboflavin in Inherited Metabolic Diseases: A Systematic Review.Journal of inherited metabolic disease · 2026Pooled it
- Treatment for mitochondrial disorders.The Cochrane database of systematic reviews · 2012Pooled it
- Clinical Diagnosis and Treatment of Leigh Syndrome Based onAntioxidants (Basel, Switzerland) · 2021Review
- Recent topics: the diagnosis, molecular genesis, and treatment of mitochondrial diseases.Journal of human genetics · 2019Review
- Prophylactic effect of riboflavin on pediatric migraine: a randomized, double-blind, placebo-controlled trial.Electronic physician · 2018Article
- Modified Atkins diet induces subacute selective ragged-red-fiber lysis in mitochondrial myopathy patients.EMBO molecular medicine · 2016Article
- Mitochondrial disease patients' perception of dietary supplements' use.Molecular genetics and metabolism · 2016Article
- New treatments for mitochondrial disease-no time to drop our standards.Nature reviews. Neurology · 2013Review
- Diagnosis and treatment of mitochondrial myopathies.Annals of medicine · 2013Review
- Therapies in inborn errors of oxidative metabolism.Trends in endocrinology and metabolism: TEM · 2012Review
- Classical MERRF phenotype associated with mitochondrial tRNA(Leu) (m.3243A>G) mutation.European journal of pediatrics · 2012Article
- Mouse studies to shape clinical trials for mitochondrial diseases: high fat diet in Harlequin mice.PloS one · 2011Article
- Mitochondrial energetics and therapeutics.Annual review of pathology · 2010Review
- Insulin and insulin resistance.The Clinical biochemist. Reviews · 2005Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We reviewed the medical records of all patients with confirmed mitochondrial diseases treated with any or all of thiamin, riboflavin, coenzyme Q, vitamin C (approximately 10 mg/kg per day) and a high-fat diet (50-60% of caloric intake) between 1997 and 2003. There were 15 patients (9 male): 10 had enzymatic deficiency and 10 had a molecular diagnosis. Age at diagnosis was 11 months to 17 years 10 months. Treatment was commenced at time of clinical diagnosis in 12 patients. Follow-up period was 3 days to 7 years (median 22 months). Improvement was reported in 9 patients, of whom 4 attained further developmental skills, but this was only temporary in 6 patients. Five patients died during the follow-up period (3 days to 7 years). Patients with the 3243A > G mutation showed no significant change in the course of their disease, except for fewer migraine attacks. Of the six patients who had seizures, one has had a significant reduction in the severity of the seizures and one has had no further seizures. Plasma lactate levels were noncontributory. We conclude that high-dose vitamin and cofactor treatment and, where applicable, high-fat diet, are well tolerated and possibly effective in the short term, but ineffective in the longer term.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.