ArticleThe Journal of experimental medicine2004
Thymic T cell development and progenitor localization depend on CCR7.
Article in The Journal of experimental medicine, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers.
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Who cites it
81 citing papers in PubMed.
- Signaling via C-C Chemokine Ligand 19 and Extracellular Regulated Kinase 5 in T Cells Limits the Humoral Adaptive Immune Response in Mice.International journal of molecular sciences · 2025Article
- Expression pattern changes of three homeologs in chemokine activity enhance antiviral response to herpesvirus infection in a newly synthesized alloheptaploid.BMC genomics · 2025Article
- Basic interactions responsible for thymus function explain the convoluted medulla shape.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- The Inflammatory-Immune Axis in Thyroid Disease: A Mendelian Randomization Study.International journal of endocrinology · 2025Article
- Intrathymic Cell Migration: Implications in Thymocyte Development and T Lymphocyte Repertoire Formation.Advances in experimental medicine and biology · 2025Review
- Disruption of the moonlighting function of CTF18 in a patient with T-lymphopenia.Frontiers in immunology · 2025Article
- Atypical chemokine receptors in the immune system.Nature reviews. Immunology · 2024Review
- The thymus road to a T cell: migration, selection, and atrophy.Frontiers in immunology · 2024Review
- CCR4 and CCR7 differentially regulate thymocyte localization with distinct outcomes for central tolerance.eLife · 2023Article
- Tracking Regulatory T Cell Development in the Thymus Using Single-Cell RNA Sequencing/TCR Sequencing.Journal of immunology (Baltimore, Md. : 1950) · 2022Article
- Cellular Electrical Impedance as a Method to Decipher CCR7 Signalling and Biased Agonism.International journal of molecular sciences · 2022Article
- Endothelial SIRPα signaling controls VE-cadherin endocytosis for thymic homing of progenitor cells.eLife · 2022Article
- Chemokine receptor CCR9 suppresses the differentiation of CD4Mucosal immunology · 2022Article
- AiScience · 2022Article
- αβ/γδ T cell lineage outcome is regulated by intrathymic cell localization and environmental signals.Science advances · 2021Article
- The regulatory function of mixed lineage kinase 3 in tumor and host immunity.Pharmacology & therapeutics · 2021Review
- Thymus and autoimmunity.Seminars in immunopathology · 2021Review
- Medullary stromal cells synergize their production and capture of CCL21 for T-cell emigration from neonatal mouse thymus.Blood advances · 2021Article
- The pathogenic importance of CCL21 and CCR7 in rheumatoid arthritis.Cytokine & growth factor reviews · 2020Review
- PU.1 regulates Ccr7 gene expression by binding to its promoter in naïve CD4FEBS open bio · 2020Article
21 more citing papers are in PubMed but not listed here.
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7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
T cell differentiation in the adult thymus depends on sequential interactions between lymphoid progenitors and stromal cells found in distinct regions of the cortex and medulla. Therefore, migration of T cell progenitors through distinct stromal environments seems to be a crucial process regulating differentiation and homeostasis inside the thymus. Here we show that CCR7-deficient mice are distinguished by a disturbed thymic architecture, impaired T cell development, and decreased numbers of the thymocytes. Analysis of developing double negative (CD4-CD8-) pool of wild-type thymus reveals that CCR7 expression is restricted to a CD25intCD44+ subpopulation. Correspondingly, CCR7 deficiency results in an accumulation of this population in mutant thymus. Furthermore, immunohistology shows that in CCR7-deficient mice CD25+CD44+ cells accumulate at the cortico-medullary junction, suggesting that CCR7 signaling regulates the migration of early progenitors toward the outer thymic cortex, thereby continuing differentiation. Results obtained from mixed bone marrow chimeras support this view, since the development of CCR7-deficient thymocytes is also disturbed in a morphologically intact thymus. Thus, our findings establish an essential role for CCR7 in intrathymic migration and proper T cell development.
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