ArticleEukaryotic cell2004
The forkhead transcription factor Fkh2 regulates the cell division cycle of Schizosaccharomyces pombe.
Article in Eukaryotic cell, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 53 citations in OpenAlex.
- Evolution of the Cell-Cycle Clock Models: Biochemical or Transcriptional?Advances in experimental medicine and biology · 2026Review
- The zinc bound form of the actinomycete derived natural product compound JBIR-141 induces a mitotic phenotype in fission yeast.Scientific reports · 2025Article
- Article
- Local chromatin context regulates the genetic requirements of the heterochromatin spreading reaction.PLoS genetics · 2022Article
- Transcription factor SsFoxE3 activating SsAtg8 is critical for sclerotia, compound appressoria formation, and pathogenicity in Sclerotinia sclerotiorum.Molecular plant pathology · 2022Article
- Cyclin/Forkhead-mediated coordination of cyclin waves: an autonomous oscillator rationalizing the quantitative model of Cdk control for budding yeast.NPJ systems biology and applications · 2021Review
- CSL protein regulates transcription of genes required to prevent catastrophic mitosis in fission yeast.Cell cycle (Georgetown, Tex.) · 2016Article
- Cuf2 Is a Transcriptional Co-Regulator that Interacts with Mei4 for Timely Expression of Middle-Phase Meiotic Genes.PloS one · 2016Article
- Principal component analysis based unsupervised feature extraction applied to budding yeast temporally periodic gene expression.BioData mining · 2016Article
- Article
- A new transcription factor for mitosis: in Schizosaccharomyces pombe, the RFX transcription factor Sak1 works with forkhead factors to regulate mitotic expression.Nucleic acids research · 2015Article
- Transcriptional control of fungal cell cycle and cellular events by Fkh2, a forkhead transcription factor in an insect pathogen.Scientific reports · 2015Article
- Fission Yeast CSL Transcription Factors: Mapping Their Target Genes and Biological Roles.PloS one · 2015Article
- Regulation of Ace2-dependent genes requires components of the PBF complex in Schizosaccharomyces pombe.Cell cycle (Georgetown, Tex.) · 2015Article
- Roles of Forkhead-box Transcription Factors in Controlling Development, Pathogenicity, and Stress Response in Magnaporthe oryzae.The plant pathology journal · 2014Article
- Regulation of wee1(+) expression during meiosis in fission yeast.Cell cycle (Georgetown, Tex.) · 2014Article
- An Atg10-like E2 enzyme is essential for cell cycle progression but not autophagy in Schizosaccharomyces pombe.Cell cycle (Georgetown, Tex.) · 2013Article
- Cyclin-dependent kinase 8 regulates mitotic commitment in fission yeast.Molecular and cellular biology · 2012Article
- A homeodomain transcription factor regulates the DNA replication checkpoint in yeast.Cell cycle (Georgetown, Tex.) · 2011Article
- Deconvolution of chromatin immunoprecipitation-microarray (ChIP-chip) analysis of MBF occupancies reveals the temporal recruitment of Rep2 at the MBF target genes.Eukaryotic cell · 2011Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
In eukaryotes the regulation of gene expression plays a key role in controlling cell cycle progression. Here, we demonstrate that a forkhead transcription factor, Fkh2, regulates the periodic expression of cdc15(+) and spo12(+) in the M and G(1) phases of the cell division cycle in the fission yeast Schizosaccharomyces pombe. We also show that Fkh2 is important for several cell cycle processes, including cell morphology and cell separation, nuclear structure and migration, and mitotic spindle function. We find that the expression of fkh2(+) is itself regulated in a cell cycle-dependent manner in G(1) coincident with the expression of cdc18(+), a Cdc10-regulated gene. However, fkh2(+) expression is independent of Cdc10 function. Fkh2 was found to be phosphorylated during the cell division cycle, with a timing that suggests that this posttranslational modification is important for cdc15(+) and spo12(+) expression. Related forkhead proteins regulate G(2) and M phase-specific gene expression in the evolutionarily distant Saccharomyces cerevisiae, suggesting that these proteins play conserved roles in regulating cell cycle processes in eukaryotes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.