Evidence map›Paper›PMID 15302735›Full record

Trial reportChest2004

Quality of life after coronary artery bypass graft: results from the POST CABG Trial.

Norma Lynn Fox, Byron J Hoogwerf, Susan Czajkowski, Ruth Lindquist, Gilles Dupuis, J Alan Herd, Lucien Campeau, Ann Hickey, Franca B Barton, Michael L Terrin and 1 more

Registry-linked trialAbstract readClinical TrialRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Chest, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It reports registered trial NCT00000463. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00000463 phase3completed

Post Coronary Artery Bypass Graft (CABG) Study

Ran1987Registered outcomes0Posted comparisons0ConditionsCardiovascular Diseases, Coronary Disease, Heart Diseases, Myocardial IschemiaArmscholestyramine, lovastatin, warfarin
PMID 8988902PMID 2784541PMID 1556345PMID 14660996PMID 11723015PMID 9863740PMID 9860374PMID 9402435PMID 9257071PMID 9114757PMID 8992351PMID 11137831other papers from this trial
Open the trial in the graph
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 11 citations in OpenAlex.

  1. Trial
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 7 institutions in 2 countries.

Norma Lynn FoxMaryland Medical Research Institute, Baltimore, MD, USA. normalynn_fox@HGSI.com
Byron J Hoogwerf
Susan Czajkowski
Ruth Lindquist
Gilles Dupuis
J Alan Herd
Lucien Campeau
Ann Hickey
Franca B Barton
Michael L Terrin
POST CABG Study Investigators
Maryland Medical Research Institute · USMontreal Heart Institute · CABaylor College of Medicine · USCedars-Sinai Medical Center · USCleveland Clinic · USNational Heart Lung and Blood Institute · USUniversity of Minnesota · US

Funding

POST CORONARY ARTERY BYPASS GRAFT STUDYN01HC075071 · HC · BAYLOR COLLEGE OF MEDICINE · PI HERD, J ALAN · 1987 to 1995
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POST CORONARY ARTERY BYPASS GRAFT STUDYN01HC075072 · HC · CEDARS-SINAI MEDICAL CENTER · PI FORRESTER, JAMES S · 1987 to 1995
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POST CORONARY ARTERY BYPASS GRAFT STUDYN01HC075073 · HC · CLEVELAND CLINIC FOUNDATION · PI HOOGWERF, BYRON J · 1987 to 1995
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POST CORONARY ARTERY BYPASS GRAFT STUDYN01HC075074 · HC · UNIVERSITY OF MINNESOTA TWIN CITIES · PI HUNNINGHAKE, DONALD B · 1987 to 1997
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POST CORONARY ARTERY BYPASS GRAFT STUDYN01HC075075 · HC · MONTREAL HEART INSTITUTE · PI CAMPEAU, LUCIEN · 1987 to 1997
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POST CORONARY ARTERY BYPASS GRAFT STUDYN01HC075076 · HC · MARYLAND MEDICAL RESEARCH INSTITUTE, INC · PI KNATTERUD, GENELL L · 1987 to 1999
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NHLBI NIH HHS N01-HC-75071NHLBI NIH HHS N01-HC-75072NHLBI NIH HHS N01-HC-75073NHLBI NIH HHS N01-HC-75074NHLBI NIH HHS N01-HC-75075NHLBI NIH HHS N01-HC-75076
6 · The paper itself

Abstract

objectivesThe POST CABG (Post Coronary Artery Bypass Graft) Trial showed that aggressive lowering of low-density lipoprotein (LDL) cholesterol levels reduced the progression of atherosclerosis in saphenous vein grafts. In the extended follow-up phase, aggressive lowering of LDL cholesterol levels was associated with reduced rates of clinical events. Low-dose anticoagulation therapy did not reduce the progression of atherosclerosis. We conducted this analysis to determine the effects of both lipid-lowering and low-dose anticoagulation therapy on health-related quality of life (HRQL).

designRandomized clinical trial, factorial design.

settingOutpatients in five tertiary care medical centers. PATIENTS: A cohort of 852 patients enrolled in the POST CABG Trial completed an HRQL questionnaire at baseline, and at the year 2 and year 4 follow-up visits.

interventionAggressive LDL cholesterol lowering vs moderate LDL cholesterol lowering, and low-dose warfarin vs placebo. MEASUREMENTS: Domains included emotional status, basic physical and social functioning, perceived health status, symptoms of pain, a variety of physical symptoms, and global life satisfaction.

resultsOverall, there were no indications of systematic differences among treatment groups for any of the HRQL parameters at baseline, year 2, or year 4.

conclusionsThese data indicate that patients did not experience detrimental or beneficial effects on HRQL parameters while receiving LDL cholesterol-lowering therapy that had demonstrable benefits for treatment of atherosclerosis.

Indexed as

Coronary Artery BypassQuality of LifeAnticoagulantsArteriosclerosisCholesterol, LDLDisease ProgressionFemaleHumansMalePostoperative CareSurveys and QuestionnairesWarfarinAnticoagulantsCholesterol, LDLWarfarin

Identifiers

PMID15302735
OpenAlexW2158062159

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.