ArticleBritish journal of pharmacology2004
Inhibitory pathways in the circular muscle of rat jejunum.
Article in British journal of pharmacology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed, 22 citations in OpenAlex.
- The role of nitric oxide and L-type calcium channel blocker in the contractility of rabbit ileum in vitro.Journal of physiology and biochemistry · 2012Article
- Roles for pituitary adenylate cyclase-activating peptide (PACAP) expression and signaling in the bed nucleus of the stria terminalis (BNST) in mediating the behavioral consequences of chronic stress.Journal of molecular neuroscience : MN · 2010Review
- Small intestinal motility in soluble guanylate cyclase alpha1 knockout mice: (Jejunal phenotyping of sGCalpha1 knockout mice).Naunyn-Schmiedeberg's archives of pharmacology · 2009Article
- Gene therapy of Cav1.2 channel with VIP and VIP receptor agonists and antagonists: a novel approach to designing promotility and antimotility agents.American journal of physiology. Gastrointestinal and liver physiology · 2008Article
- Effects of extrinsic denervation on innervation with VIP and substance P in circular muscle of rat jejunum.Neurogastroenterology and motility · 2008Article
- Long-term effects of extrinsic denervation on VIP and substance P innervation in circular muscle of rat jejunum.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2007Article
- Study on the cyclic GMP-dependency of relaxations to endogenous and exogenous nitric oxide in the mouse gastrointestinal tract.British journal of pharmacology · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. Conflicting data have been reported on the contribution of nitric oxide (NO) to inhibitory neurotransmission in rat jejunum. Therefore, the mechanism of relaxation and contribution to inhibitory neurotransmission of NO, adenosine 5'-triphosphate (ATP), vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating peptide (PACAP) was examined in the circular muscle of Wistar-Han rat jejunum. 2. Mucosa-free circular muscle strips were precontracted with methacholine in the presence of guanethidine and exposed to electrical field stimulation (EFS) and exogenous NO, ATP, VIP and PACAP. All stimuli induced reduction of tone and inhibition of phasic motility. Only electrically induced responses were sensitive to tetrodotoxin (3 x 10(-6) m). 3. NO (10(-6)-10(-4) m)-induced concentration-dependent relaxations that were inhibited by the soluble guanylyl cyclase inhibitor 1H-[1,2,4]-oxadiazolo-[4,3-a]-quinoxalin-1-one (ODQ; 10(-5) m) and the small conductance Ca(2+)-activated K(+)-channel blocker apamin (APA; 3 x 10(-8) m). 4. Relaxations elicited by exogenous ATP (10(-4)-10(-3) m) were inhibited by the P2Y purinoceptor antagonist reactive blue 2 (RB2; 3 x 10(-4) m), but not by APA and ODQ. 5. The inhibitory responses evoked by 10(-7) m VIP and 3 x 10(-8) m PACAP were decreased by the selective PAC(1) receptor antagonist PACAP(6-38) (3 x 10(-6) m) and APA. The VPAC(2) receptor antagonist PG99-465 (3 x 10(-7) m) reduced relaxations caused by VIP, but not those by PACAP, while the VPAC(1) receptor antagonist PG97-269 (3 x 10(-7) m) had no influence. 6. EFS-induced relaxations were inhibited by the NO-synthase inhibitor N(omega)-nitro-l-arginine methyl ester (3 x 10(-4) m), ODQ and APA, but not by RB2, PG97-269, PG99-465 and PACAP(6-38). 7. These results suggest that NO is the main inhibitory neurotransmitter in the circular muscle of Wistar-Han rat jejunum acting through a rise in cyclic guanosine monophosphate levels and activation of small conductance Ca(2+)-dependent K(+) channels.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.