ArticleWorld journal of gastroenterology2004
Glutamine supplemented parenteral nutrition prevents intestinal ischemia- reperfusion injury in rats.
Article in World journal of gastroenterology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 57 citations in OpenAlex.
- Zinc, vitamin A, and glutamine supplementation in Brazilian shantytown children at risk for diarrhea results in sex-specific improvements in verbal learning.Clinics (Sao Paulo, Brazil) · 2013Trial
- Intra-abdominal infection combined with intra-abdominal hypertension aggravates the intestinal mucosal barrier dysfunction.Bioscience reports · 2018Article
- Protective effect of glutamine on the main and adjacent organs damaged by ischemia-reperfusion in rats.Protoplasma · 2017Article
- Effects of glutamine on markers of intestinal inflammatory response and mucosal permeability in abdominal surgery patients: A meta-analysis.Experimental and therapeutic medicine · 2016Article
- Glutamine ameliorates intestinal ischemia-reperfusion Injury in rats by activating the Nrf2/Are signaling pathway.International journal of clinical and experimental pathology · 2015Article
- Temporal relationship of serum markers and tissue damage during acute intestinal ischemia/reperfusion.Clinics (Sao Paulo, Brazil) · 2013Article
- Dietary glutamine supplementation prevents mucosal injury and modulates intestinal epithelial restitution following acetic acid induced intestinal injury in rats.Nutrition & metabolism · 2013Article
- Gut inflammation in chronic fatigue syndrome.Nutrition & metabolism · 2010Article
- Food fight! Parenteral nutrition, enteral stimulation and gut-derived mucosal immunity.Langenbeck's archives of surgery · 2009Review
- Enteral glutamine pretreatment does not decrease plasma endotoxin level induced by ischemia-reperfusion injury in rats.World journal of gastroenterology · 2008Article
- Dietary glutamine supplementation prevents mucosal injury and modulates intestinal epithelial restitution following ischemia-reperfusion injury in the rat.Digestive diseases and sciences · 2007Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo examine whether glutamine prevents the injury to the intestinal mucosa after intestinal ischemia-reperfusion (I/R) in rats.
methodsThirty male Sprague-Dawley rats were randomly divided into 3 groups: a standard parenteral nutrition (PN) group (n = 10); an I/R-PN group (n = 10); an I/R-glutamine enriched PN (I/R-Gln) group (n = 10). The superior mesenteric artery (SMA) was clamped. After 60 min of ischemia, reperfusion was initiated and infusion was started. All rats received isocaloric and isonitrogenous nutritional support for 48 h. Spleen, liver, mesenteric lymph nodes (MLN), and intestinal segments were removed for morphological and biochemical analyses, and blood samples were collected for bacterial culture and measurement of endotoxin levels. The permeability of intestinal mucosa was assayed by measurement of D-(-)-lactate levels in plasma.
resultsIn I/R-PN group, extensive epithelial atrophy was observed, mucosal thickness, villous height, crypt depth and villous surface area were decreased significantly compared with PN group, whereas these findings did not occur in the I/R-Gln group. The incidence of intestinal bacterial translocation to spleen, liver, MLN, and blood was significantly higher in I/R-PN group than that in other groups. Plasma endotoxin levels significantly increased in the I/R-PN group compared with the I/R-Gln group. Remarkably higher values of D-(-)-lactate were also detected in PN group compared with that in I/R-Gln group.
conclusionGlutamine protects the morphology and function of intestinal mucosa from injury after I/R in rats.
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