ReviewPediatric nephrology (Berlin, Germany)2004
A 20-year history of childhood HIV-associated nephropathy.
Review in Pediatric nephrology (Berlin, Germany), 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 62 citations in OpenAlex.
- Association of Perinatal HIV Exposure and HIV Disease Severity With BP in Youth.Hypertension (Dallas, Tex. : 1979) · 2026Article
- Pathogenesis of HIV-associated nephropathy in children and adolescents: taking a hard look 40 years later in the era of gene-environment interactions.American journal of physiology. Renal physiology · 2024Review
- HIV-associated nephropathy in children: challenges in a resource-limited setting.Pediatric nephrology (Berlin, Germany) · 2023Review
- Circulating fibroblast growth factor-2 precipitates HIV nephropathy in mice.Disease models & mechanisms · 2021Article
- Brief Report: APOL1 Renal Risk Variants Are Associated With Chronic Kidney Disease in Children and Youth With Perinatal HIV Infection.Journal of acquired immune deficiency syndromes (1999) · 2016Article
- Renal abnormalities among HIV infected children at Muhimbili National Hospital (MNH)-Dar es Salaam, Tanzania.BMC nephrology · 2016Article
- Renal transplantation in human immunodeficiency virus (HIV)-positive children.Pediatric nephrology (Berlin, Germany) · 2015Review
- Predictors of resolution and persistence of renal laboratory abnormalities in pediatric HIV infection.Pediatric nephrology (Berlin, Germany) · 2015Article
- The basic domain of HIV-tat transactivating protein is essential for its targeting to lipid rafts and regulating fibroblast growth factor-2 signaling in podocytes isolated from children with HIV-1-associated nephropathy.Journal of the American Society of Nephrology : JASN · 2014Article
- Kidney disease in children and adolescents with perinatal HIV-1 infection.Journal of the International AIDS Society · 2013Review
- Proteinuria in paediatric patients with human immunodeficiency virus infection.World journal of clinical cases · 2013Review
- Chronic kidney disease associated with perinatal HIV infection in children and adolescents.Pediatric nephrology (Berlin, Germany) · 2012Article
- The spectrum of HIV-related nephropathy in children.Pediatric nephrology (Berlin, Germany) · 2012Article
- Association of nephrotic syndrome with immune reconstitution inflammatory syndrome.Pediatric nephrology (Berlin, Germany) · 2012Article
- Screening for Microalbuminuria in HIV-Positive Children in Enugu.International journal of nephrology · 2012Article
- Nephrotic proteinuria and renal involvement in HIV-infected children.Indian journal of sexually transmitted diseases and AIDS · 2011Article
- Renal manifestations in children co-infected with HIV and disseminated tuberculosis.Pediatric nephrology (Berlin, Germany) · 2010Article
- Declines in mortality rates and changes in causes of death in HIV-1-infected children during the HAART era.Journal of acquired immune deficiency syndromes (1999) · 2010Article
- Taking a hard look at the pathogenesis of childhood HIV-associated nephropathy.Pediatric nephrology (Berlin, Germany) · 2009Review
- Controversies in the pathogenesis of HIV-associated renal diseases.Nature reviews. Nephrology · 2009Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
In 1984, physicians in New York and Miami reported HIV-infected adult patients with heavy proteinuria and rapid progression to end-stage renal disease. These patients showed large edematous kidneys with a combination of focal segmental glomerulosclerosis (FSGS) and tubulointerstitial lesions. This renal syndrome, named HIV-associated nephropathy (HIVAN), was found predominantly in African Americans. Subsequent studies confirmed the presence of HIVAN in children, who frequently develop nephrotic syndrome in association with FSGS and/or mesangial hyperplasia with microcystic tubular dilatation. Since then, substantial progress has been made in our understanding of the etiology and pathogenesis of HIVAN. This article reviews 20 years of research into the pathogenesis of HIVAN and discusses how these concepts could be applied to the treatment of children with HIVAN. HIV-1 infection plays a direct role in the pathogenesis of childhood HIVAN, at least partially by affecting the growth and differentiation of glomerular and tubular epithelial cells and enhancing the renal recruitment of infiltrating mononuclear cells and cytokines. An up-regulation of renal heparan sulfate proteoglycans seems to play a relevant role in this process, by increasing the recruitment of heparin-binding growth factors (i.e., FGF-2), chemokines, HIV-infected cells, and viral proteins (i.e., gp120, Tat). These changes enhance the infectivity of HIV-1 in the kidney and induce injury and proliferation of intrinsic renal cells. Highly active anti-retroviral therapy (HAART) appears to be the most promising treatment to prevent the progression of childhood HIVAN. Hopefully, in the near future, better education, prevention, and treatment programs will lead to the eradication of this fatal childhood disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.