ArticleHistochemistry and cell biology2004
The functional architecture of the nucleus as analysed by ultrastructural cytochemistry.
Article in Histochemistry and cell biology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed.
- Resolving Sub-Nuclear Architecture from Compartments to Functional Domains.International journal of molecular sciences · 2026Review
- Differential Expression of Lamins and Modulation of Chromatin Architecture in Carcinogenesis: tous pour un et un pour tous.Sub-cellular biochemistry · 2025Review
- Chromatin Organization after High-LET Irradiation Revealed by Super-Resolution STED Microscopy.International journal of molecular sciences · 2024Article
- Function moves biomolecular condensates in phase space.BioEssays : news and reviews in molecular, cellular and developmental biology · 2022Article
- Genome organization around nuclear speckles.Current opinion in genetics & development · 2019Review
- Ultrastructural localization of 5-methylcytosine on DNA and RNA.Cellular and molecular life sciences : CMLS · 2017Article
- Coming to terms with chromatin structure.Chromosoma · 2016Review
- Compartmentalization and Functionality of Nuclear Disorder: Intrinsic Disorder and Protein-Protein Interactions in Intra-Nuclear Compartments.International journal of molecular sciences · 2015Article
- Analysis of ERK3 intracellular localization: dynamic distribution during mitosis and apoptosis.European journal of histochemistry : EJH · 2015Article
- Intrinsically disordered proteins in the nucleus of human cells.Biochemistry and biophysics reports · 2015Article
- Nuclear ribonucleoprotein-containing foci increase in size in non-dividing cells from patients with myotonic dystrophy type 2.Histochemistry and cell biology · 2012Article
- Article
- Atomic force microscope imaging of chromatin assembled in Xenopus laevis egg extract.Chromosoma · 2011Article
- RNA processing is altered in skeletal muscle nuclei of patients affected by myotonic dystrophy.Histochemistry and cell biology · 2011Article
- Organization of transcription.Cold Spring Harbor perspectives in biology · 2010Review
- Dynamics of single mRNP nucleocytoplasmic transport and export through the nuclear pore in living cells.Nature cell biology · 2010Article
- The cell nuclei of skeletal muscle cells are transcriptionally active in hibernating edible dormice.BMC cell biology · 2009Article
- Nuclear bodies in Douglas fir (Pseudotsuga menziesii Mirb.) microspores.Protoplasma · 2008Article
- Use of halogenated precursors for simultaneous DNA and RNA detection by means of immunoelectron and immunofluorescence microscopy.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2008Article
- Single-cell c-myc gene expression in relationship to nuclear domains.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ultrastructural cytochemistry has been, for many years now, a major tool for investigating structure-function relationships in the cell nucleus. It has been essential in approaching the roles which different nuclear structural constituents can play in nuclear functions. This article briefly summarises transmission electron microscopic studies aimed at characterising in situ nuclear architectural domains and their involvement in main nuclear functions, such as DNA replication, hnRNA transcription and pre-mRNA processing. It discusses the importance of ultrastructural cytochemistry in high resolution analyses of intranuclear distribution of chromatin domains and their topological relationships with other structural interphase nuclear constituents. It puts forward the central role of the perichromatin region as a functional nuclear domain. Finally, it attempts to critically evaluate some future applications of ultrastructural investigations of the nucleus and stresses the importance of combining them with light microscopic analyses of living cells.
Indexed as
Identifiers
15300441What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.