ReviewJournal of mammary gland biology and neoplasia2004
A crucial role for fibroblast growth factor signaling in embryonic mammary gland development.
Review in Journal of mammary gland biology and neoplasia, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 39 citations in OpenAlex.
- Long-chain noncoding RNA sequencing analysis reveals the molecular profiles of chemically induced mammary epithelial cells.Frontiers in genetics · 2023Article
- Peroxidasin Enhances Basal Phenotype and Inhibits Branching Morphogenesis in Breast Epithelial Progenitor Cell Line D492.Journal of mammary gland biology and neoplasia · 2021Article
- The functional effects and mechanisms by which fibroblast growth factor 2 (FGF2) controls bovine mammary epithelial cells: Implications for the development and functionality of the bovine mammary gland.Journal of animal science · 2017Article
- FGFR2 risk SNPs confer breast cancer risk by augmenting oestrogen responsiveness.Carcinogenesis · 2016Article
- RasGAP Shields Akt from Deactivating Phosphatases in Fibroblast Growth Factor Signaling but Loses This Ability Once Cleaved by Caspase-3.The Journal of biological chemistry · 2015Article
- FGF ligands of the postnatal mammary stroma regulate distinct aspects of epithelial morphogenesis.Development (Cambridge, England) · 2014Article
- A study on genetic variants of Fibroblast growth factor receptor 2 (FGFR2) and the risk of breast cancer from North India.PloS one · 2014Article
- The FGF/FGFR axis as a therapeutic target in breast cancer.Expert review of endocrinology & metabolism · 2013Article
- Pleiotropic functions of fibroblast growth factor signaling in embryonic mammary gland development.Journal of mammary gland biology and neoplasia · 2013Review
- Tumor-specific isoform switch of the fibroblast growth factor receptor 2 underlies the mesenchymal and malignant phenotypes of clear cell renal cell carcinomas.Clinical cancer research : an official journal of the American Association for Cancer Research · 2013Article
- Development of Foreign Mammary Epithelial Morphology in the Stroma of Immunodeficient Mice.PloS one · 2013Article
- Fibroblast growth factor receptor signaling is essential for normal mammary gland development and stem cell function.Stem cells (Dayton, Ohio) · 2013Article
- Article
- Phenotype-genotype correlation in familial breast cancer.Journal of mammary gland biology and neoplasia · 2011Review
- Estrogen expands breast cancer stem-like cells through paracrine FGF/Tbx3 signaling.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Article
- Fibroblast growth factor signalling: from development to cancer.Nature reviews. Cancer · 2010Review
- Breast cancer susceptibility alleles and ovarian cancer risk in 2 study populations.International journal of cancer · 2009Article
- Common integration sites for MMTV in viral induced mouse mammary tumors.Journal of mammary gland biology and neoplasia · 2008Review
- Mouse modifier genes in mammary tumorigenesis and metastasis.Journal of mammary gland biology and neoplasia · 2008Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The fibroblast growth factors (Fgfs) represent a large group of intercellular signaling molecules that mediate their effects by binding to a class of cell surface enzymes belonging to the receptor tyrosine kinase family (FgfRs). In vitro, Fgf signaling can induce potent mitogenic, motogenic, and angiogenic cellular responses, and has been associated with a multitude of biological processes. The development of gene targeting and transgenic strategies has provided unequivocal evidence for the key involvement of Fgf signaling in mammalian developmental processes. In this review we highlight recent findings that demonstrate a critical requirement for Fgf signaling in the induction and development of the embryonic mammary gland. Furthermore, we briefly discuss the potential of Fgfs to act as oncogenic factors in mammary neoplasia.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.