ReviewJournal of mammary gland biology and neoplasia2004
Msx-1 and Msx-2 in mammary gland development.
Review in Journal of mammary gland biology and neoplasia, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 54 citations in OpenAlex.
- Review
- Co-Evolution of Breast Milk Lipid Signaling and Thermogenic Adipose Tissue.Biomolecules · 2021Review
- Cul3 is required for normal development of the mammary gland.Cell and tissue research · 2021Article
- Msx Homeobox Genes Act Downstream of BMP2 to Regulate Endometrial Decidualization in Mice and in Humans.Endocrinology · 2019Article
- The biological significance of methylome differences in human papilloma virus associated head and neck cancer.Oncology letters · 2016Article
- Search for regulatory factors of the pituitary-specific transcription factor PROP1 gene.The Journal of reproduction and development · 2016Article
- Uncovering molecular events associated with the chemosuppressive effects of flaxseed: a microarray analysis of the laying hen model of ovarian cancer.BMC genomics · 2014Article
- Induction of Apoptosis and Growth Suppression by Homeobox Gene TGIFLX in Prostate Cancer Cell Line Lncap.Iranian journal of public health · 2013Article
- BMP-binding protein twisted gastrulation is required in mammary gland epithelium for normal ductal elongation and myoepithelial compartmentalization.Developmental biology · 2013Article
- DNAJB6 governs a novel regulatory loop determining Wnt/β-catenin signalling activity.The Biochemical journal · 2012Article
- Phosphorylated and sumoylation-deficient progesterone receptors drive proliferative gene signatures during breast cancer progression.Breast cancer research : BCR · 2012Article
- Role of Cripto-1 during epithelial-to-mesenchymal transition in development and cancer.The American journal of pathology · 2012Review
- MSX2 in pancreatic tumor development and its clinical application for the diagnosis of pancreatic ductal adenocarcinoma.Frontiers in physiology · 2012Article
- MSX2 is an oncogenic downstream target of activated WNT signaling in ovarian endometrioid adenocarcinoma.Oncogene · 2011Article
- Functional and prognostic relevance of the homeobox protein MSX2 in malignant melanoma.British journal of cancer · 2011Article
- Selection of brain metastasis-initiating breast cancer cells determined by growth on hard agar.The American journal of pathology · 2011Article
- The oncogenic role of Yin Yang 1.Critical reviews in oncogenesis · 2011Review
- Article
- Expression of MSX2 predicts malignancy of branch duct intraductal papillary mucinous neoplasm of the pancreas.Journal of gastroenterology · 2010Article
- Homeobox transcription factor muscle segment homeobox 2 (Msx2) correlates with good prognosis in breast cancer patients and induces apoptosis in vitro.Breast cancer research : BCR · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Homeobox genes do not generally function alone to determine cell fate and morphogenesis. Rather it is the distinct combination of various members of the homeobox family of genes and their spatiotemporal patterns of expression that determine cell identity and function. Functional redundancy often makes it difficult to clearly discern the role of any one given homeobox gene. The roles that Msx1 and Msx2 play in branching morphogenesis of the mammary gland are only now becoming more evident. Many signaling pathways and transcription factors are implicated in how these homeobox genes correctly determine the morphological development of the gland. Overexpression of Msx1 and Msx2 may also be involved in tumorigenesis. Additional studies are needed to elucidate the roles of these genes in both breast development and cancer.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.