ReviewJournal of mammary gland biology and neoplasia2004
Next stop, the twilight zone: hedgehog network regulation of mammary gland development.
Review in Journal of mammary gland biology and neoplasia, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 70 citations in OpenAlex.
- Emergence of Nanotechnology as a Powerful Cavalry against Triple-Negative Breast Cancer (TNBC).Pharmaceuticals (Basel, Switzerland) · 2022Review
- Cellular Plasticity in Breast Cancer Progression and Therapy.Frontiers in molecular biosciences · 2020Review
- Review
- Signaling pathways involved in chronic myeloid leukemia pathogenesis: The importance of targeting Musashi2-Numb signaling to eradicate leukemia stem cells.Iranian journal of basic medical sciences · 2019Review
- Hedgehog Pathway Inhibitors and Their Utility in Basal Cell Carcinoma: A Comprehensive Review of Current Evidence.Dermatology and therapy · 2019Review
- Sonic hedgehog signaling in epithelial tissue development.Regenerative medicine research · 2019Article
- The role of the Hedgehog signaling pathway in cancer: A comprehensive review.Bosnian journal of basic medical sciences · 2018Review
- Involvement of hedgehog pathway in early onset, aggressive molecular subtypes and metastatic potential of breast cancer.Cell communication and signaling : CCS · 2018Article
- Potential therapeutic targets of triple-negative breast cancer based on its intrinsic subtype.Oncotarget · 2017Review
- Review
- Normal mammary development and function in mice with Ift88 deleted in MMTV- and K14-Cre expressing cells.Cilia · 2014Article
- Hedgehog and Gli signaling in embryonic mammary gland development.Journal of mammary gland biology and neoplasia · 2013Review
- Evo-devo of the mammary gland.Journal of mammary gland biology and neoplasia · 2013Review
- Norcantharidin, derivative of cantharidin, for cancer stem cells.Evidence-based complementary and alternative medicine : eCAM · 2013Review
- Old and new stories: revelations from functional analysis of the bovine mammary transcriptome during the lactation cycle.PloS one · 2012Article
- Implications of cancer stem cell theory for cancer chemoprevention by natural dietary compounds.The Journal of nutritional biochemistry · 2011Review
- Article
- The mammary gland microenvironment directs progenitor cell fate in vivo.International journal of cell biology · 2011Article
- Hedgehog signaling in the normal and neoplastic mammary gland.Current drug targets · 2010Review
- Primary cilia regulate branching morphogenesis during mammary gland development.Current biology : CB · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The hedgehog signal transduction network is a critical mediator of cell-cell communication during embryonic development. Evidence also suggests that properly regulated hedgehog network function is required in some adult organs for stem cell maintenance or renewal. Mutation, or misexpression, of network genes is implicated in the development of several different types of cancer, particularly that of skin, brain, lung, and pancreas. Recent studies in the mouse mammary gland have demonstrated roles for hedgehog network genes at virtually every phase of mammary gland development where it regulates such diverse processes as embryonic mammary gland induction, establishment of ductal histoarchitecture, and functional differentiation in lactation. Further, studies suggest a role for misregulated network function in the progression of breast cancer.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.