Evidence map›Paper›PMID 15300008›Full record

ReviewJournal of mammary gland biology and neoplasia2004

Wnt proteins in mammary development and cancer.

Keith R Brennan, Anthony M C Brown

Abstract readReview
PubMed Publisher
In one paragraph

Review in Journal of mammary gland biology and neoplasia, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 123 papers.

0numbers the graph read from it
0cells of the map it votes in
123citing papers in PubMed
6.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

123 citing papers in PubMed, 247 citations in OpenAlex.

  1. Trial
  2. Article
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  4. Review
  5. Review
  6. Review
  7. Article
  8. Article
  9. Ezh2 promotes mammary tumor initiation through epigenetic regulation of the Wnt and mTORC1 signaling pathways.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  10. Review
  11. Review
  12. Review
  13. Article
  14. Article
  15. Article
  16. Review
  17. Wnt/β-catenin signaling in cancers and targeted therapies.Signal transduction and targeted therapy · 2021
    Review
  18. Article
  19. Article
  20. Article

63 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

Keith R BrennanSchool of Biological Sciences, University of Manchester, Manchester, United Kingdom.
Anthony M C Brown
Cornell University · USUniversity of Manchester · GB

Funding

Wnt signaling in mammary development and cancerR01CA047207 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI BROWN, ANTHONY M.C. · 1996 to 2006
$2.0M
ACTION OF THE ONCOGENE INT-1 IN MAMMARY TUMORSR29CA047207 · NCI · WEILL MEDICAL COLLEGE OF CORNELL UNIV · PI BROWN, ANTHONY M.C. · 1988 to 1992
–
NCI NIH HHS CA47207NCI NIH HHS R01 CA047207
6 · The paper itself

Abstract

Secreted proteins of the Wnt family play widespread roles in the regulation of embryonic development, and aberrant activation of the canonical Wnt/beta-catenin pathway is one of the most frequent signaling abnormalities known in human cancer. While the consequences of Wnt signaling in development are diverse at the cellular level, they are often concerned with cell fate determination. Recent data also indicate that Wnt proteins influence the self-renewal of stem cells in certain tissues. In the mammary gland, Wnt signals are strongly implicated in initial development of the mammary rudiments, and in the ductal branching and alveolar morphogenesis that occurs during pregnancy. Transgenic expression of Wnt1 or Wnt10b in the mouse mammary gland leads to lobuloalveolar hyperplasia with a major risk of progression to carcinoma. Recent evidence suggests that this phenotype is associated with expansion of a multipotent progenitor cell population. In human breast cancer, evidence of beta-catenin accumulation implies that the canonical Wnt signaling pathway is active in over 50% of carcinomas. However, specific mutations that might account for this activation of signaling have not yet been identified.

Indexed as

BreastBreast NeoplasmsCell DifferentiationCell MovementCell PolarityIntercellular Signaling Peptides and ProteinsMammary Glands, AnimalMammary Neoplasms, AnimalSignal TransductionStem CellsWnt1 ProteinWnt ProteinsIntercellular Signaling Peptides and ProteinsWnt1 ProteinWnt Proteins

Identifiers

PMID15300008
OpenAlexW2049951346

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.