Evidence map›Paper›PMID 15299144›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2004

A mechanical basis for chromosome function.

Nancy Kleckner, Denise Zickler, Gareth H Jones, Job Dekker, Ruth Padmore, Jim Henle, John Hutchinson

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 197 papers.

0numbers the graph read from it
0cells of the map it votes in
197citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

197 citing papers in PubMed.

  1. Review
  2. Article
  3. Structure and function of the synaptonemal complex.The Journal of cell biology · 2026
    Review
  4. Ufd2p promotes efficient crossover formation by destabilizing Top2p during meiosis.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Multi-step implementation of meiotic crossover patterning.bioRxiv : the preprint server for biology · 2025
    Article
  10. Sex differences in crossover interference in house mice.bioRxiv : the preprint server for biology · 2025
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Distinct and interdependent functions of three RING proteins regulate recombination during mammalian meiosis.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  18. Review
  19. Article
  20. Article

137 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Nancy KlecknerDepartment of Molecular and Cellular Biology, Harvard University, 7 Divinity Avenue, Cambridge, MA 02138, USA. kleckner@fas.harvard.edu
Denise Zickler
Gareth H Jones
Job Dekker
Ruth Padmore
Jim Henle
John Hutchinson

Funding

Structural Annotation of the Human GenomeR01HG003143 · NHGRI · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Job Dekker · 2003 to 2026
$15.4M
MEIOTIC CHROMOSOME SYNAPSIS AND RECOMBINATION IN YEASTR01GM044794 · NIGMS · HARVARD UNIVERSITY · PI KLECKNER, NANCY E · 1990 to 2018
$13.8M
ILLEGITIMATE RECOMBINATION BY DRUG RESISTANCE ELEMENTSR01GM025326 · NIGMS · HARVARD UNIVERSITY · PI KLECKNER, NANCY E · 1985 to 2019
$12.5M
ILLEGITIMATE RECOMBINATION BY DRUG RESISTANCE ELEMENTSR37GM025326 · NIGMS · HARVARD UNIVERSITY · PI KLECKNER, NANCY E. · 1991 to 2000
$656k
NHGRI NIH HHS HG 03143NHGRI NIH HHS R01 HG003143NIGMS NIH HHS GM 25326NIGMS NIH HHS GM 44794NIGMS NIH HHS R01 GM025326NIGMS NIH HHS R01 GM044794NIGMS NIH HHS R37 GM025326
6 · The paper itself

Abstract

We propose that chromosome function is governed by internal mechanical forces generated by programmed tendencies for expansion of the DNA/chromatin fiber against constraining features.

Indexed as

AnimalsChromatinChromosomesDNA, PlantHumansMeiosisMitosisModels, BiologicalNucleic Acid ConformationStress, MechanicalTime FactorsChromatinDNA, Plant

Identifiers

PMID15299144
PMCPMC515102

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.