ArticleBiophysical journal2004
Imaging neuronal seal resistance on silicon chip using fluorescent voltage-sensitive dye.
Article in Biophysical journal, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 61 citations in OpenAlex.
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- Numerical study on the effect of capacitively coupled electrical stimulation on biological cells considering model uncertainties.Scientific reports · 2022Article
- Electrophysiology Read-Out Tools for Brain-on-Chip Biotechnology.Micromachines · 2021Review
- Inorganic semiconductor biointerfaces.Nature reviews. Materials · 2018Article
- Visualization of electrical field of electrode using voltage-controlled fluorescence release.Computers in biology and medicine · 2016Article
- Current-Induced Transistor Sensorics with Electrogenic Cells.Biosensors · 2016Review
- Trends and Challenges in Neuroengineering: Toward "Intelligent" Neuroprostheses through Brain-"Brain Inspired Systems" Communication.Frontiers in neuroscience · 2016Article
- Interfacing Cultured Neurons to Microtransducers Arrays: A Review of the Neuro-Electronic Junction Models.Frontiers in neuroscience · 2016Review
- Optically transparent multi-suction electrode arrays.Frontiers in neuroscience · 2015Article
- A CMOS IC-based multisite measuring system for stimulation and recording in neural preparations in vitro.Frontiers in neuroengineering · 2014Article
- Response characteristics of single-cell impedance sensors employed with surface-modified microelectrodes.Biosensors & bioelectronics · 2010Article
- Spine-shaped gold protrusions improve the adherence and electrical coupling of neurons with the surface of micro-electronic devices.Journal of the Royal Society, Interface · 2009Article
- Implantable Microimagers.Sensors (Basel, Switzerland) · 2008Review
- Solution of the Poisson-Nernst-Planck equations in the cell-substrate interface.The European physical journal. E, Soft matter · 2007Article
- The mechanism of extracellular stimulation of nerve cells on an electrolyte-oxide-semiconductor capacitor.Biophysical journal · 2007Article
- The extracellular electrical resistivity in cell adhesion.Biophysical journal · 2006Article
- Neural Monitoring With CMOS Image Sensors.Basic and clinical neuroscienceArticle
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The electrical sheet resistance between living cells grown on planar electronic contacts of semiconductors or metals is a crucial parameter for bioelectronic devices. It determines the strength of electrical signal transduction from cells to chips and from chips to cells. We measured the sheet resistance by applying AC voltage to oxidized silicon chips and by imaging the voltage change across the attached cell membrane with a fluorescent voltage-sensitive dye. The phase map of voltage change was fitted with a planar core-coat conductor model using the sheet resistance as a free parameter. For nerve cells from rat brain on polylysine as well as for HEK293 cells and MDCK cells on fibronectin we find a similar sheet resistance of 10 MOmega. Taking into account the independently measured distance of 50 nm between chip and membrane for these cells, we obtain a specific resistance of 50 Omegacm that is indistinguishable from bulk electrolyte. On the other hand, the sheet resistance for erythrocytes on polylysine is far higher, at approximately 1.5 GOmega. Considering the distance of 10 nm, the specific resistance in the narrow cleft is enhanced to 1500 Omegacm. We find this novel optical method to be a convenient tool to optimize the interface between cells and chips for bioelectronic devices.
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