ArticleBMC gastroenterology2004
Nitric oxide-an endogenous inhibitor of gastric acid secretion in isolated human gastric glands.
Article in BMC gastroenterology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 31 citations in OpenAlex.
- Effects of the long-term influence of bisphenol A and bisphenol S on the population of nitrergic neurons in the enteric nervous system of the mouse stomach.Scientific reports · 2023Article
- The Role of Gasotransmitters in Gut Peptide Actions.Frontiers in pharmacology · 2021Review
- Induction of Secretagogue Independent Gastric Acid SecretionFrontiers in physiology · 2019Article
- Sodium hydrosulfide upregulates mRNA and protein expression of TGF-α in gastric mucosa in experimental model of stimulated gastric acid secretion in rats.Iranian journal of basic medical sciences · 2017Article
- Protective Effects of Simvastatin Against Alendronate-Induced Gastric Mucosal Injury in Rats.Digestive diseases and sciences · 2016Article
- Antisecretory effect of hydrogen sulfide on gastric acid secretion and the involvement of nitric oxide.BioMed research international · 2014Article
- The effects of capsaicin on gastrin secretion in isolated human antral glands: before and after ingestion of red chilli.Digestive diseases and sciences · 2009Article
- Effect of nitric oxide on histamine-induced cytological transformations in parietal cells in isolated human gastric glands.Digestive diseases and sciences · 2007Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEndothelial nitric oxide synthase (eNOS) has previously been detected in the glandular part of the human gastric mucosa. Furthermore, nitric oxide (NO) has been shown to influence gastric secretion in various animal models. The present study was conducted to investigate the influence of exogenously and endogenously derived NO on histamine- and cAMP-stimulated gastric acid secretion in isolated human oxyntic glands.
methodsOxyntic glands were isolated from human gastric biopsies and were subsequently pre-treated with NO donors and nitric oxide synthase inhibitors and then exposed to histamine or dibutyryl-cAMP (db-cAMP). The secretory response of the glands was determined as accumulation of [14C]aminopyrine.
resultsThe histamine- or db-cAMP-induced acid secretion was attenuated by L-arginine, a known source of endogenous NO, and also by the NO-donors sodium nitroprusside (SNP) and S-nitroso-N-acetyl-penicillamine (SNAP). Pre-treatment with either of the NOS inhibitors NG-nitro-L-arginine methyl ester (L-NAME) or NG-nitro-L-arginine (L-NNA) enhanced the secretory response.
conclusionOur results show that NO inhibits gastric acid secretion in isolated human gastric glands, and that there is endogenous formation of NO within the glandular epithelium in the vicinity of the parietal cells.
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