ArticleClinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology2004
Allergic airway inflammation is exacerbated during acute influenza infection and correlates with increased allergen presentation and recruitment of allergen-specific T-helper type 2 cells.
Article in Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed, 46 citations in OpenAlex.
- The H3K27me3-NR1D1-IFN-γ axis in trained macrophages induced by early respiratory virus infection drives non-T2 asthma in children.Cellular & molecular immunology · 2026Article
- The Environmental Microbiome, Allergic Disease, and Asthma.The journal of allergy and clinical immunology. In practice · 2022Article
- Influenza Vaccination Is Associated With Lower Incidental Asthma Risk in Patients With Atopic Dermatitis: A Nationwide Cohort Study.Frontiers in immunology · 2021Article
- Impaired virus replication and decreased innate immune responses to viral infections in nasal epithelial cells from patients with allergic rhinitis.Clinical and experimental immunology · 2017Article
- IL-12 Signals through the TCR To Support CD8 Innate Immune Responses.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- Group 2 innate lymphoid cell production of IL-5 is regulated by NKT cells during influenza virus infection.PLoS pathogens · 2013Article
- Allergic airway disease in mice alters T and B cell responses during an acute respiratory poxvirus infection.PloS one · 2013Article
- The microbiology of asthma.Nature reviews. Microbiology · 2012Review
- Article
- Respiratory viral infections in infants: causes, clinical symptoms, virology, and immunology.Clinical microbiology reviews · 2010Review
- Exacerbation of allergic inflammation in mice exposed to diesel exhaust particles prior to viral infection.Particle and fibre toxicology · 2009Article
- Immunization with live influenza viruses in an experimental model of allergic bronchial asthma: infection and vaccination.Influenza and other respiratory viruses · 2008Article
- Innate immunity to influenza virus: implications for future therapy.Expert review of clinical immunology · 2008Article
- A key role for CC chemokine receptor 1 in T-cell-mediated respiratory inflammation.The American journal of pathology · 2008Article
- Role of CCL5 (RANTES) in viral lung disease.Journal of virology · 2006Article
- Respiratory viral infections drive chemokine expression and exacerbate the asthmatic response.The Journal of allergy and clinical immunology · 2006Review
- Article
- Unravelling synergistic immune interactions between respiratory virus infections and allergic airway inflammation.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2004Article
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4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRespiratory viral infections are a leading cause of the hospitalization of asthmatics, however, the cellular immunological interactions which underlie these two diseases remain elusive.
objectiveWe sought to characterize the effect influenza viral infection has on allergic airway inflammation and to identify the cellular pathways involved.
methodsWe have used an ovalbumin (OVA) model of allergic airway inflammation, which involves sensitization of animals with OVA adsorbed in alum adjuvant followed by an intranasal challenge with OVA in phosphate-buffered saline. To study T cell recruitment into the lung, we adoptively transferred in vitro activated T cell receptor-transgenic T cells, which were subsequently identified by fluorescence-activated cell sorting (FACS) analysis. In addition, to study in vivo dendritic cell (DC) migration, we administered fluorescently labelled dextran and identified DCs that had phagocytosed it by FACS analysis.
resultsWe found that different stages of influenza infection had contrasting effects upon the outcome of OVA-induced allergic airway inflammation. The allergic response against OVA was exacerbated during the acute stage of influenza infection; however, mice were protected against the development of airway eosinophilia at late time-points following infection. We investigated the mechanisms responsible for the virus-induced exacerbation and found that the response was partially independent of IL-4 and that there was increased delivery of inhaled allergens to the draining lymph node during the acute stage of the infection. In addition, virus-induced inflammation in the lung and draining lymph node resulted in the non-specific recruitment of circulating allergen-specific effector/memory cells.
conclusionIn addition to virus-mediated damage to the lung and airways, influenza viral infection can also enhance unrelated local allergic responses.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.