ArticleClinical cardiology2004
Association between paraoxonase-1 activity and lipid peroxidation indicator levels in people living in the Antalya region with angiographically documented coronary artery disease.
Article in Clinical cardiology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03646019 (Serum Oxidative Status as a Potential Predictor of Coronary Artery Disease.), which is not on this map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Serum Oxidative Status as a Potential Predictor of Coronary Artery Disease.
Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- Exploring the role of paraoxonases in the pathogenesis of coronary artery disease: a systematic review.International journal of molecular sciences · 2014Pooled it
- Is elevated serum ceruloplasmin level associated with increased risk of coronary artery disease?The Canadian journal of cardiology · 2008Trial
- The role of inflammation, oxidation and Cystatin-C in the pathophysiology of polycystic ovary syndrome.Turkish journal of obstetrics and gynecology · 2022Article
- [Serum annexin A2 level is significantly elevated in patients with coronary heart disease].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2020Article
- Cross-sectional correlates of paraoxonase 1 and soluble intercellular adhesion molecule-1 in metabolic syndrome patients with and without diabetes.Therapeutic advances in endocrinology and metabolism · 2018Article
- Decreased paraoxonase1 activity and increased malondialdehyde and oxidative DNA damage levels in primary open angle glaucoma.International journal of ophthalmology · 2016Article
- The concentration of thiobarbituric acid reactive substances (TBARS) and paraoxonase activity in blood of patients with osteoarthrosis after endoprosthesis implantation.Medical science monitor : international medical journal of experimental and clinical research · 2011Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundParaoxonase-1 (PON1) is a high-density lipoprotein (HDL)-associated enzyme capable of hydrolyzing lipid peroxides. Thus, PON1 plays a preventing role in atherosclerosis by protecting against lipid peroxidation. HYPOTHESIS: The incidence of coronary artery disease (CAD) is high in the Turkish population, and many risk factors have been studied as determinants of CAD. In Turkish people living in the Antalya region, we aimed to determine serum PON1 activity and its relation to lipoproteins and lipid peroxidation markers.
methodsWe measured the activity of serum PON1 together with concentrations of a variety of lipid constituents--total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), very low-density lipoprotein cholesterol (VLDL-C), HDL cholesterol (HDL-C), triglycerides (TG), apolipoprotein (apo) A-I, apoB, and lipid peroxidation indicators (conjugated diene [CD] and thiobarbituric acid-reactive substances [TBARS])--in 108 patients with CAD and 64 healthy subjects (controls).
resultsWe found that the PON1 activity was significantly reduced in patients with CAD (222.37 +/- 11.31 IU/l) compared with controls (331.75 +/- 20.98 IU/l). These patients had significantly lower HDL-C, PON1/HDL-C, apoA-I, PON1/ApoA-I, and ApoA-I/ApoB, and higher LDL-C, TC/HDL-C, LDL-C/HDL-C, apoB, CD and TBARS than did controls. Total cholesterol and apoA-I concentrations were significantly higher in women than in men in both groups. After multiple logistic regression analysis, TBARS (odds ratio [OR] 568.87; p = 0.000), age (OR 1.10; p = 0.000), gender (OR 4.58; p = 0.008), apoA-I/apoB (OR 0.046; p = 0.003), and PON1/apoA-I (OR 0.58; p = 0.007) were independently indicative of the presence of CAD.
conclusionsThis is the first report of decreased serum PON1 activity and increased lipid peroxidation indicators (CD and TBARS) of patients with CAD living in Antalya, Turkey. Our results indicate that TBARS levels, age, gender, apoA-1/ApoB, and PON1/apoA-I ratios are important markers of CAD.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.