ArticleProceedings of the National Academy of Sciences of the United States of America2004
Essential role for virus-neutralizing antibodies in sterilizing immunity against Friend retrovirus infection.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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Who cites it
31 citing papers in PubMed, 51 citations in OpenAlex.
- Heterologous prime-pull mucosal vaccination with an adjuvanted RBD vaccine elicits robust IgA production and protects against SARS-CoV-2.Frontiers in immunology · 2025Article
- Prolonged Protective Immunity Induced by Mild SARS-CoV-2 Infection of K18-hACE2 Mice.Vaccines · 2022Article
- COVID-19 Vaccines Currently under Preclinical and Clinical Studies, and Associated Antiviral Immune Response.Vaccines · 2020Review
- Koala retrovirus epidemiology, transmission mode, pathogenesis, and host immune response in koalas (Phascolarctos cinereus): a review.Archives of virology · 2020Review
- Immunization with a murine cytomegalovirus based vector encoding retrovirus envelope confers strong protection from Friend retrovirus challenge infection.PLoS pathogens · 2019Article
- Regulatory T cells suppress virus-specific antibody responses to Friend retrovirus infection.PloS one · 2018Article
- B Cell Requirement for Robust Regulatory T Cell Responses to Friend Retrovirus Infection.mBio · 2017Article
- Induction of complex immune responses and strong protection against retrovirus challenge by adenovirus-based immunization depends on the order of vaccine delivery.Retrovirology · 2017Article
- Filariae-Retrovirus Co-infection in Mice is Associated with Suppressed Virus-Specific IgG Immune Response and Higher Viral Loads.PLoS neglected tropical diseases · 2016Article
- Antibodies Are Required for Complete Vaccine-Induced Protection against Herpes Simplex Virus 2.PloS one · 2015Article
- Elimination of friend retrovirus in the absence of CD8+ T cells.Journal of virology · 2014Article
- Humoral immunity in the Friend retrovirus infection model.Immunologic research · 2013Review
- Intraosseous inoculation of tumor cells into bone marrow promotes distant metastatic tumor development: A novel tool for mechanistic and therapeutic studies.Cancer letters · 2013Article
- Article
- Interleukin-encoding adenoviral vectors as genetic adjuvant for vaccination against retroviral infection.PloS one · 2013Article
- Noninfectious retrovirus particles drive the APOBEC3/Rfv3 dependent neutralizing antibody response.PLoS pathogens · 2011Article
- Toll-like receptor 7 controls the anti-retroviral germinal center response.PLoS pathogens · 2011Article
- Improved vaccine protection against retrovirus infection after co-administration of adenoviral vectors encoding viral antigens and type I interferon subtypes.Retrovirology · 2011Article
- Persistence of viremia and production of neutralizing antibodies differentially regulated by polymorphic APOBEC3 and BAFF-R loci in friend virus-infected mice.Journal of virology · 2010Article
- Complement as an endogenous adjuvant for dendritic cell-mediated induction of retrovirus-specific CTLs.PLoS pathogens · 2010Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The current experiments use the Friend retrovirus model to demonstrate that vaccine-primed B cells are essential for sterilizing immunity, and the results indicate that the requisite function of these cells is the production of virus-neutralizing antibodies rather than priming or reactivation of T cells. B cell-deficient mice were poorly protected by vaccination, but adoptive transfer experiments showed that the T cells from B cell-deficient mice were primed as well as those from wild-type mice. Furthermore, passive transfer of virus-neutralizing antibodies completely compensated for B cell deficiency. The presence of virus-neutralizing antibodies at the time of infection was crucial for vaccine efficacy. Interestingly, virus-neutralizing antibodies worked synergistically with vaccine-primed T cells to provide a level of protection many orders of magnitude greater than either antibodies or immune T cells alone. Nonneutralizing antibodies also contributed to protection and acted cooperatively with neutralizing antibodies to reduce infection levels. These results emphasize the importance of inducing both T cell responses and virus-neutralizing antibody responses for effective retroviral vaccine protection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.