ArticleThe Journal of physiology2004
Albumin transcytosis across the epithelium of the lactating mouse mammary gland.
Article in The Journal of physiology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 56 citations in OpenAlex.
- Article
- Transfer of celiac disease-associated immunogenic gluten peptides in breast milk: variability in kinetics of secretion.Frontiers in immunology · 2024Article
- Antimicrobial Activity of Milk Whey in Different Mammals.Bulletin of experimental biology and medicine · 2023Article
- Breast Milk: A Potential Route of Tick-Borne Encephalitis Virus Transmission from Mother to Infant.Cureus · 2023Review
- Clathrin-Mediated Albumin Clearance in Alveolar Epithelial Cells of Murine Precision-Cut Lung Slices.International journal of molecular sciences · 2023Article
- Estimated Transfer of Perfluoroalkyl Substances (PFAS) from Maternal Serum to Breast Milk in Women Highly Exposed from Contaminated Drinking Water: A Study in the Ronneby Mother-Child Cohort.Environmental health perspectives · 2023Article
- Maternal Allergy and the Presence of Nonhuman Proteinaceous Molecules in Human Milk.Nutrients · 2020Article
- The Functional Power of the Human Milk Proteome.Nutrients · 2019Review
- Inclusion of grape marc in dairy cattle rations alters the bovine milk proteome.The Journal of dairy research · 2019Article
- Symposium review: Intravital imaging of the lactating mammary gland in live mice reveals novel aspects of milk-lipid secretion.Journal of dairy science · 2019Article
- Spray dried plasma as an alternative to antibiotics in piglet feeds, mode of action and biosafety.Porcine health management · 2016Review
- Endothelial caveolin-1 plays a major role in the development of atherosclerosis.Cell and tissue research · 2014Article
- Milk secretion: The role of SNARE proteins.Journal of mammary gland biology and neoplasia · 2014Review
- Lipid transport in the lactating mammary gland.Journal of mammary gland biology and neoplasia · 2014Review
- Colostrogenesis: IgG1 transcytosis mechanisms.Journal of mammary gland biology and neoplasia · 2014Review
- TALEN-mediated modification of the bovine genome for large-scale production of human serum albumin.PloS one · 2014Article
- Ductal barriers in mammary epithelium.Tissue barriers · 2013Review
- Introduction: in 1959 the electron microscope produces astounding images of the alveolar secretory cell.Journal of mammary gland biology and neoplasia · 2009Article
- Gene regulatory networks in lactation: identification of global principles using bioinformatics.BMC systems biology · 2007Article
- Secretion and fluid transport mechanisms in the mammary gland: comparisons with the exocrine pancreas and the salivary gland.Journal of mammary gland biology and neoplasia · 2006Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Murine milk contains 18 mg ml(-1) serum albumin, a concentration equal to that in the serum of the lactating mouse. We examined cellular transport using in vivo methods in the mouse. At steady state the specific activity of (125)I-albumin injected into the blood stream was equal in plasma and whey, confirming that milk albumin is extra-mammary in origin. Fluorescent albumin crossed the gland from basolateral surface to lumen via cytoplasmic vesicles, but was not transported in the apical to basal direction. Albumin was segregated from transferrin at the basal surface of the epithelial cells and did not colocalize with either caveolin-1 or -2. Vesicular transport was not disrupted by filipin providing additional evidence that, unlike the vascular endothelium, caveoli are not involved. Cytoplasmic albumin was localized to vesicles containing IgA and transport was disrupted by agents that interfere with clathrin-mediated endocytosis. Together, these findings provide evidence that albumin is transported across the mammary epithelium by the same pathway as immunoglobulin. The possibility that the massive transfer of albumin into mouse milk is mediated by fluid phase transport is considered.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.